Penetratin is an influential and transformative peptide, Penetratin revolutionizes the field of biomedicine by amplifying the efficacious influx of drugs, proteins, and nucleic acids into cellular environments. Fostering cellular internalization, this exceptional entity showcases its potential in combatting multifarious diseases such as cancer and genetic abnormalities. Capitalizing on its unparalleled prowess in cellular membrane penetration, Penetratin emerges as an auspicious instrument underpinning targeted drug administration and gene therapy assertions.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | PENETRATIN;940866-75-1;OWTCNGRIGAUCBN-IQXNUNNASA-N;AKOS040758475;G13487; |
M.F/Formula | C108H174N36O22S |
M.W/Mr. | 2360.8 |
Sequence | One Letter Code:RQIKIWFQNRRMKWKKGG Three Letter Code:H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-OH |
Appearance | Solid |
Long-term Storage Conditions | Water soluble. Avoid repeated freezing and thawing. |
InChI | InChI=1S/C108H174N36O22S/c1-6-60(3)88(144-99(160)77(40-42-84(115)146)130-90(151)67(113)30-23-48-123-106(117)118)104(165)138-73(36-18-22-47-112)98(159)143-89(61(4)7-2)105(166)142-81(54-64-57-127-69-32-14-12-29-66(64)69)102(163)139-79(52-62-26-9-8-10-27-62)100(161)136-76(39-41-83(114)145)96(157)141-82(55-85(116)147)103(164)135-75(38-25-50-125-108(121)122)93(154)133-74(37-24-49-124-107(119)120)94(155)137-78(43-51-167-5)97(158)132-72(35-17-21-46-111)95(156)140-80(53-63-56-126-68-31-13-11-28-65(63)68)101(162)134-71(34-16-20-45-110)92(153)131-70(33-15-19-44-109)91(152)129-58-86(148)128-59-87(149)150/h8-14,26-29,31-32,56-57,60-61,67,70-82,88-89,126-127H,6-7,15-25,30,33-55,58-59,109-113H2,1-5H3,(H2,114,145)(H2,115,146)(H2,116,147)(H,128,148)(H,129,152)(H,130,151)(H,131,153)(H,132,158)(H,133,154)(H,134,162)(H,135,164)(H,136,161)(H,137,155)(H,138,165)(H,139,163)(H,140,156)(H,141,157)(H,142,166)(H,143,159)(H,144,160)(H,149,150)(H4,117,118,123)(H4,119,120,124)(H4,121,122,125)/t60-,61-,67-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-/m0/s1 |
InChI Key | OWTCNGRIGAUCBN-IQXNUNNASA-N |
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