Pentafluoro-D-Phenylalanine is a non-proteinogenic, fluorinated amino acid derivative in which the phenylalanine side chain bears five fluorine atoms on the aromatic ring, and the α-carbon is specified as the D stereoisomer. The molecule contains a free amino group and a carboxyl group alongside a pentafluorophenyl side chain whose electron-withdrawing fluorination alters aromatic reactivity and hydrophobic/π-interaction characteristics relative to unfluorinated phenylalanine. It is employed in chemical biology and peptide-chemistry workflows for structure-activity studies, incorporation of fluorinated aromatic residues into peptide analogues, and analytical method development where fluorinated aromatic handles can support spectroscopic or chromatographic differentiation.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
2. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
3. Emu oil in combination with other active ingredients for treating skin imperfections
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
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