Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with Kis of 1.03 and 0.33 nM, respectively.
CAT No: R1634
CAS No:215510-22-8
Chemical Name:(3S)-4-[[(2S,3S)-1-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
Prolactin Releasing Peptide (1-31), human is a synthetic peptide corresponding to the full-length 31-amino acid sequence of the endogenous human prolactin-releasing peptide (PrRP). As a neuropeptide, PrRP is a member of the RFamide peptide family and is primarily recognized for its role in modulating prolactin secretion from the anterior pituitary. Its discovery has provided significant insights into neuroendocrine regulation, appetite control, and stress response pathways. The availability of the synthetic human (1-31) form enables researchers to investigate receptor interactions, signal transduction mechanisms, and physiological functions associated with PrRP in diverse experimental models.
Neuroendocrine signaling studies: PrRP (1-31) is widely utilized in research focused on neuroendocrine regulation, particularly in elucidating the mechanisms driving prolactin release. By applying the peptide to cultured pituitary cells or in vivo systems, investigators can stimulate prolactin secretion and analyze downstream effects, helping to clarify the functional coupling between hypothalamic signals and anterior pituitary hormone output. The peptide's specificity for the G protein-coupled PrRP receptor (GPR10) makes it a valuable tool for dissecting receptor-mediated signaling cascades in neuroendocrine tissues.
Appetite and energy balance research: The peptide is instrumental in studies exploring the central regulation of appetite and body weight. PrRP has been shown to modulate feeding behavior by acting on hypothalamic nuclei involved in satiety and energy homeostasis. Researchers employ PrRP (1-31) to probe the neurobiological pathways that control food intake, investigate potential cross-talk with other appetite-regulating neuropeptides, and model metabolic responses in rodent and cellular systems.
Stress and behavioral studies: Investigators leverage PrRP (1-31) to examine its involvement in stress response and related behavioral paradigms. The peptide's capacity to influence corticotropin-releasing hormone (CRH) neurons and activate the hypothalamic-pituitary-adrenal (HPA) axis underpins its use in experiments assessing neuropeptide-mediated modulation of stress-induced hormonal and behavioral changes. These studies contribute to a deeper understanding of how neuropeptidergic signaling integrates environmental stimuli and adaptive physiological responses.
Receptor pharmacology and ligand characterization: Synthetic PrRP (1-31) is frequently employed in receptor binding assays, functional characterization, and structure-activity relationship (SAR) studies. By serving as a reference ligand for the PrRP receptor, it enables detailed analysis of receptor activation, signal transduction, and ligand specificity. Such experiments are essential for identifying novel agonists, antagonists, or allosteric modulators with potential research or industrial applications.
Peptide-based assay development: The unique sequence and bioactivity of PrRP (1-31) support its use in the development and optimization of bioassays designed to monitor receptor function, screen for modulatory compounds, or quantify neuropeptide activity. These assays facilitate high-throughput screening in pharmaceutical research, enable validation of analytical methodologies, and support mechanistic studies in neurobiology and endocrinology. By providing a reliable standard, the peptide enhances experimental reproducibility and data interpretation in peptide-focused research workflows.
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