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Protease-Activated Receptor-2 Activating Peptide

Protease-Activated Receptor-2 Activating Peptide is an agonist of Protease-Activated Receptor-2 (PAR-2).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Protease-Activated Receptor-2 Activating Peptide(CAS 171436-38-7)

CAT No: R1636

CAS No:171436-38-7

Synonyms/Alias:SLIGRL-NH2;171436-38-7;H-SER-LEU-ILE-GLY-ARG-LEU-NH2;SL-NH2;CHEMBL238078;Ser-Leu-Ile-Gly-Arg-Leu-NH2;(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-N-[2-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-methylpentanamide;Ser-Leu-Ile-Gly-Arg-Leu-amide;Ser-Leu-Ile-Gly-Arg-Leu-NH(2);PAR-2 activation peptide;SLIGRL-NH2?;SLIGRL-NH2 2TFA;seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide;PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt;BDBM85517;C29H56N10O7;HY-P1308;BDBM50477070;HB2920;AKOS024456619;AKOS040763878;AS-82543;DA-77885;FP109453;SLIGRL (modifications: C-terminal amide);CAS_171436-38-7;CS-0029354;G13181;H-Ser-Leu-Ile-Gly-Arg-Leu-NH2; H-SLIGRL-NH2;PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt, >=97% (HPLC);(2S,3S)-2-[(2S)-2-[(2S)-2-AMINO-3-HYDROXYPROPANAMIDO]-4-METHYLPENTANAMIDO]-N-({[(1S)-4-CARBAMIMIDAMIDO-1-{[(1S)-1-CARBAMOYL-3-METHYLBUTYL]CARBAMOYL}BUTYL]CARBAMOYL}METHYL)-3-METHYLPENTANAMIDE;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C29H56N10O7
M.W/Mr.
656.8
Sequence
One Letter Code:SLIGRL
Three Letter Code:H-Ser-Leu-Ile-Gly-Arg-Leu-NH2
Biological Activity
Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.
Long-term Storage Conditions
Soluble to 1 mg/ml in water
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1
InChI Key
SGPMJRPYYIJZPC-JYAZKYGWSA-N

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