Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
CAT No: R1652
CAS No:129121-73-9
Synonyms/Alias:129121-73-9;CGRP 8-37 (rat);AKOS024456433;FC109404;PD079006;G12622;
Rat CGRP-(8-37) is a synthetic peptide fragment corresponding to amino acids 8 through 37 of the rat calcitonin gene-related peptide (CGRP) sequence. As a well-characterized CGRP receptor antagonist, this peptide is widely employed in neurobiology and vascular biology research to investigate the physiological and pathophysiological roles of endogenous CGRP signaling. Its structural specificity enables selective blockade of CGRP-mediated pathways, making it a valuable probe for dissecting the complex mechanisms underlying nociception, vasoregulation, and neuropeptide-receptor interactions in rodent models. The availability of this peptide fragment has significantly advanced the study of CGRP receptor pharmacology, facilitating the exploration of both central and peripheral biological processes modulated by CGRP.
Receptor antagonist studies: As a competitive antagonist of the CGRP receptor, Rat CGRP-(8-37) is extensively used to delineate the functional contributions of CGRP signaling in various physiological systems. By selectively inhibiting CGRP-induced responses, researchers can differentiate between receptor-mediated effects and those arising from alternative pathways. This approach is instrumental in clarifying the specific involvement of CGRP in neurogenic inflammation, pain transmission, and vascular tone regulation, particularly in rat tissue preparations and in vivo models.
Neuroscience research: The peptide fragment serves as a critical tool in neurobiological investigations focused on sensory processing and pain mechanisms. By applying Rat CGRP-(8-37) in electrophysiological, behavioral, or molecular studies, scientists can probe the role of CGRP in modulating synaptic transmission, neuronal excitability, and neuropeptide release. Its use has been pivotal in elucidating the contribution of CGRP to migraine pathophysiology, hyperalgesia, and central sensitization, providing mechanistic insights that inform broader neurophysiological theories.
Vascular function assays: In vascular biology, Rat CGRP-(8-37) is frequently utilized to assess the impact of CGRP on arterial relaxation, vasodilation, and blood flow dynamics. The peptide's ability to antagonize CGRP-mediated vasorelaxant effects allows for precise evaluation of endogenous CGRP activity in isolated vessel preparations, perfused organ systems, and ex vivo tissue assays. Such studies are essential for understanding the regulation of vascular tone and the role of neuropeptides in cardiovascular homeostasis.
Pharmacological profiling: The compound is valuable in the pharmacological characterization of novel CGRP receptor ligands, antagonists, or modulators. By serving as a reference antagonist, Rat CGRP-(8-37) enables comparative analysis of binding affinities, functional potencies, and receptor subtype selectivities. This application is particularly relevant for drug discovery programs focused on neuropeptide signaling pathways, as it supports the validation of assay systems and the identification of lead compounds with therapeutic potential.
Peptide-receptor interaction studies: Rat CGRP-(8-37) is also employed in structural and mechanistic studies investigating the molecular determinants of peptide-receptor recognition and antagonism. Its defined sequence and established activity profile make it suitable for mapping receptor binding domains, conducting mutagenesis experiments, and modeling ligand-receptor interactions. Such research contributes to a deeper understanding of G protein-coupled receptor (GPCR) architecture and the principles governing peptide hormone signaling in mammalian systems.
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