(Sar1,Gly8)-Angiotensin II is an angiotensin analog containing sarcosine at position 1 and glycine at position 8, adjustments known to influence receptor interaction and metabolic stability. The substitutions modify N-terminal rigidity and C-terminal flexibility. Such changes support tuning of signaling profiles at angiotensin receptors. Researchers use it to probe critical residues governing pressor peptide recognition.
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