Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10).
CAT No: HB00114
CAS No:80714-61-0
Synonyms/Alias:Semax;80714-61-0;ACTH (4-7), Pro-Gly-Pro-;MEHFPGP;Met-Glu-His-Phe-Pro-Gly-Pro;I5FAL2585H;ACTH (4-7), prolyl-glycyl-proline-;Pro-gly-pro-acth (4-7);UNII-I5FAL2585H;L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline;(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid;L-Proline, 1-(N-(1-(N-(N-(N-L-methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-prolyl)glycyl)-;Semax?;H-Met-Glu-His-Phe-Pro-Gly-Pro-OH;SCHEMBL7200319;GLXC-25922;HY-P1146;AKOS040744795;AT42448;DA-77788;Met-Glu-His-Phe-Pro-Gly-Pro [WHO-DD];CS-0028296;methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline;L-PROLINE, L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-PROLYLGLYCYL-;L-PROLINE, L-METHIONYL-L-alpha-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-PROLYLGLYCYL-;
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment, designed to mimic specific regulatory functions in the central nervous system. As a peptide compound, it is characterized by its stability and resistance to enzymatic degradation, making it a valuable tool in neurobiological and biochemical research. Its sequence and structure allow it to interact with various neuroreceptors and modulate neurotransmitter systems, granting researchers a unique probe for investigating peptide-mediated signaling pathways and neuroregulatory mechanisms. The ability of Semax to influence synaptic activity and neuroplasticity has positioned it as a molecule of considerable interest in the study of neural function, learning, and memory processes.
Neuropharmacological research: Semax is widely utilized in neuropharmacological studies aimed at elucidating the mechanisms of peptide-based neuromodulation. Its selective activity on the central nervous system enables researchers to investigate the roles of melanocortin peptides in synaptic transmission, neuroprotection, and cognitive modulation. By serving as a model compound for the study of ACTH-derived peptides, it facilitates the exploration of receptor interactions, signal transduction pathways, and downstream gene expression relevant to neural plasticity and homeostasis.
Peptide structure-activity relationship (SAR) studies: The unique sequence and functional properties of Semax make it an ideal candidate for structure-activity relationship investigations within the field of peptide chemistry. Researchers employ this heptapeptide to dissect the contributions of individual amino acid residues to biological activity, receptor affinity, and metabolic stability. Such studies provide critical insights into the design of novel neuroactive peptides, optimization of therapeutic leads, and the development of peptide analogs with tailored pharmacological profiles.
Molecular mechanism elucidation: Semax serves as a valuable molecular tool for probing the intracellular signaling cascades activated by ACTH-related peptides. Its application in cell-based assays and biochemical experiments allows for the detailed characterization of second messenger systems, such as cyclic AMP and calcium flux, as well as the identification of transcriptional responses induced by peptide stimulation. This facilitates a deeper understanding of the molecular underpinnings of neuropeptide action and the cellular processes governing neuronal adaptation and resilience.
Neurotoxicity and neuroprotection modeling: In experimental models of neuronal injury, oxidative stress, or excitotoxicity, Semax is frequently employed to assess mechanisms of neuroprotection and cellular survival. Its modulatory effects on antioxidant systems and anti-apoptotic pathways provide a platform for evaluating the efficacy of peptide-based interventions in mitigating neural damage. Such applications are pivotal for advancing knowledge of endogenous protective mechanisms and for screening new compounds that may influence neuronal viability.
Peptide delivery and stability research: The physicochemical properties of Semax, particularly its resistance to proteolytic degradation, render it a model substrate in studies focused on peptide delivery systems and bioavailability enhancement. Researchers utilize it to test innovative formulation approaches, such as nanoparticle encapsulation or intranasal administration, to improve central nervous system targeting and prolong peptide activity. These investigations contribute to the broader field of peptide drug development by informing strategies for optimizing the delivery and persistence of bioactive peptides in biological systems.
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