Sincalide

Name: Sincalide
Brand: Creative Peptides
SKU: R1676
Availability: MadeToOrder

Sincalide is an octapeptide fragment of cholestocystokinin (CCK) that activates the CCK receptor on immune cell surfaces. Sincalide is more potent when sulfated. Sincalide exhibits neuroprotective, immunosuppressive, and anorexigenic activities.

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CAT No: R1676

CAS No: 25126-32-3

Synonyms/Alias: Sincalide;25126-32-3;CCK-8;Sincalida;Kinevac;Sincalidum;Syncalide;CCK C-terminal octapeptide;SQ 19844;Human CCK-8;cholecystokinin C-terminal octapeptide;Cholecystokinin octapeptide;UNII-M03GIQ7Z6P;3-10-Caerulein, 5-L-methionine-;M03GIQ7Z6P;DTXSID7048617;SQ-19844;Sincalidum [INN-Latin];EINECS 246-639-0;Sincalida [INN-Spanish];MFCD00079849;Cholecystokinin-pancreozymin;H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2;Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-;CHEMBL1121;DTXCID4028543;Sincalide [USAN:USP:INN:BAN];L-Aspartyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide hydrogen sulfate (ester);Sincalidum (INN-Latin);1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein;Sincalida (INN-Spanish);SINCALIDE (MART.);SINCALIDE [MART.];cholecystokinin 8;L-alpha-Aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide;SINCALIDE (USP IMPURITY);SINCALIDE [USP IMPURITY];Sincalide (USAN:USP:INN:BAN);(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid;(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosanedioic acid;CAS-25126-32-3;CCK-8 (sulphated);CCK-OP;OP-CCK;CCK-8S;NCGC00183278-01;NCGC00183363-01;Kinevac (TN);SINCALIDE [INN];SINCALIDE [MI];CCK Octapeptide sulfated;Sincalide (USAN/INN);SINCALIDE [USAN];SINCALIDE [VANDF];SINCALIDE [WHO-DD];GTPL864;Cholecystokinin Pancreozymin C Terminal Octapeptide;Cholecystokinin Pancreozymin C-Terminal Octapeptide;SCHEMBL122365;CCK-8(SO3);SINCALIDE [ORANGE BOOK];BDBM21147;EX-A8006C;V04CC03;CHEBI:135946;Pancreozymin C-terminal octapeptide;[125I]CCK-8;HY-P0093;Tox21_112955;Tox21_113481;AKOS016340423;CS-5963;DB09142;FS41124;HS-2026;NCGC00167273-01;Cholecystokinin, CCK Octapeptide (26-33);NS00050642;D05845;E78048;Asp26-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2;CHOLECYSTOKININ C-TERMINAL OCTAPEPTIDE [MI];EN300-19650945;Q7521885;(3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carboxypropanamido]-3-[4-(sulfooxy)phenyl]propanamido]-4-(methylsulfanyl)butanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid;(3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-amino-3-formamidopropanoic acid]-3-[4-(sulfooxy)phenyl]propanamido]-4-(methylsulfanyl)butanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid;(3S)-3-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-3-(4-sulfooxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid;(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid;(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-((S)-1-amino-1-oxo-3-phenylpropan-2-ylcarbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid;246-639-0;L-.ALPHA.-ASPARTYL-O-SULFO-L-TYROSYL-L-METHIONYLGLYCYL-L-TRYPTOPHYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANINAMIDE;L-Aspartyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide Hydrogen Sulfate(ester);

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M.F/Formula	C49H62N10O16S3
M.W/Mr.	1143.3
Sequence	One Letter Code:DXMGWMDF Three Letter Code:H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
Biological Activity	Sincalide (Cholecystokinin octapeptide) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is an agent that promotes gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. The hepatobiliary physiologic effect of Sincalide ammonium is to increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum.

Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
InChI Key	IZTQOLKUZKXIRV-YRVFCXMDSA-N

1. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

2. Cationic cell-penetrating peptides are potent furin inhibitors

3. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line

4. Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications

5. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

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