TB500 is a synthetic version of an active region of thymosin β4. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | TB500;885340-08-9;UNII-QHK6Z47GTG;QHK6Z47GTG;TB-500;(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid;TB 500;L-Glutamine, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-alpha-glutamyl-L-threonyl-;(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid; TB 500;HY-P0170;TB 500 acetate;GLXC-26514;EX-A7411;TB500?;Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH;AKOS040763972;CS-6213;DA-58320;FT183581;MS-31657;G16402;(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3R)-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-acetamido-4-methylpentanamido]hexanamido]hexanamido]-3-hydroxybutanamido]-4-carboxybutanamido]-3-hydroxybutanamido]-4-carbamoylbutanoic acid; |
M.F/Formula | C38H68N10O14 |
M.W/Mr. | 889 |
Sequence | One Letter Code:LKKTETQ Three Letter Code:Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH |
Purity | >98% |
Long-term Storage Conditions | H2O : 50 mg/mL (56.24 mM; Need ultrasonic) |
Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
InChI | InChI=1S/C38H68N10O14/c1-19(2)18-27(42-22(5)51)35(58)44-23(10-6-8-16-39)32(55)43-24(11-7-9-17-40)33(56)47-30(20(3)49)36(59)45-25(13-15-29(53)54)34(57)48-31(21(4)50)37(60)46-26(38(61)62)12-14-28(41)52/h19-21,23-27,30-31,49-50H,6-18,39-40H2,1-5H3,(H2,41,52)(H,42,51)(H,43,55)(H,44,58)(H,45,59)(H,46,60)(H,47,56)(H,48,57)(H,53,54)(H,61,62)/t20-,21-,23+,24+,25+,26+,27+,30+,31+/m1/s1 |
InChI Key | ADKDNDYYIZUVCZ-ZQNQAVPYSA-N |
1. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
3. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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