TB500 is a synthetic version of an active region of thymosin β4. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation.
CAT No: R1711
CAS No:885340-08-9
Synonyms/Alias:TB500;885340-08-9;UNII-QHK6Z47GTG;QHK6Z47GTG;TB-500;(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid;TB 500;L-Glutamine, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-alpha-glutamyl-L-threonyl-;(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid; TB 500;HY-P0170;TB 500 acetate;GLXC-26514;EX-A7411;TB500?;Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH;AKOS040763972;CS-6213;DA-58320;FT183581;MS-31657;G16402;(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3R)-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-acetamido-4-methylpentanamido]hexanamido]hexanamido]-3-hydroxybutanamido]-4-carboxybutanamido]-3-hydroxybutanamido]-4-carbamoylbutanoic acid;
TB500, also known as Thymosin Beta-4 Acetate, is a synthetic peptide modeled after the naturally occurring thymosin beta-4 protein found in various tissues. As a peptide compound, it plays a significant role in cellular processes related to actin regulation, cytoskeletal organization, and tissue remodeling. Its ability to influence cell migration and differentiation has made it a focal point in a variety of experimental research settings, particularly those investigating cellular repair mechanisms and tissue dynamics. Researchers value TB500 for its well-characterized sequence and versatility in peptide-based studies, making it a prominent tool in the field of molecular and cellular biology.
Peptide mechanism studies: TB500 serves as an important reagent for investigating the molecular pathways underlying actin polymerization and cytoskeletal rearrangement. By providing a reliable source of thymosin beta-4 activity, it enables researchers to dissect the specific interactions between actin monomers and regulatory peptides, facilitating a deeper understanding of cytoskeletal dynamics. These insights are critical for elucidating the fundamental processes that govern cell shape, motility, and intracellular transport.
Cell migration assays: In vitro and ex vivo studies frequently employ TB500 to evaluate its effect on cell motility and migration. The peptide's involvement in actin filament modulation allows experimental systems to model wound healing, tissue regeneration, and developmental processes where directed cell movement is essential. Its use in scratch assays, transwell migration setups, and 3D culture models helps clarify the molecular cues that guide cells during tissue repair and morphogenesis.
Peptide synthesis and analytical validation: TB500 is commonly used as a reference standard or calibration agent in peptide synthesis laboratories. Its well-defined sequence and established analytical profile make it suitable for validating chromatographic methods, mass spectrometry protocols, and peptide purification workflows. Researchers and technical staff rely on it to optimize synthesis yields, assess purity, and benchmark analytical instrumentation in peptide chemistry environments.
Tissue engineering research: The peptide's capacity to influence cellular behavior has led to its adoption in tissue engineering studies. By incorporating TB500 into biomaterial scaffolds or cell culture systems, scientists can investigate how peptide-mediated signaling affects cell proliferation, extracellular matrix deposition, and tissue organization. These applications are essential for developing advanced biomaterials and engineered tissues for research purposes, fostering innovation in regenerative biology.
Protein-protein interaction studies: TB500 offers a valuable model for probing the interactions between regulatory peptides and cytoskeletal proteins. By utilizing labeled or modified forms of the peptide, researchers can perform binding assays, co-immunoprecipitation experiments, and fluorescence-based studies to map interaction sites and affinities. These experiments provide mechanistic insights into how peptides modulate protein networks, supporting the design of novel molecular tools and research reagents in cell biology.
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