Tetrapeptide-21

Tetrapeptide-21 is a synthetic peptide composed of four amino acids, designed for use in cosmetic formulations targeting skin appearance and texture. Recognized for its role in supporting the skin's extracellular matrix, Tetrapeptide-21 is valued in anti-aging and skin care products. Its compatibility with various formulation types and stability under standard cosmetic processing conditions make it a versatile ingredient for innovative product development. Suitable for global regulatory compliance.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Tetrapeptide-21(CAS 960608-17-7)

CAT No: CPC1703

CAS No:960608-17-7

Synonyms/Alias:Tetrapeptide-21;Gly-glu-lys-gly;960608-17-7;GEKG;Tego pep 4-17;GEKG peptide;UNII-179JUC43HU;179JUC43HU;Glycine, glycyl-l-alpha-glutamyl-l-lysyl-;DTXSID80242108;(4S)-4-[(2-aminoacetyl)amino]-5-[[(2S)-6-amino-1-(carboxymethylamino)-1-oxohexan-2-yl]amino]-5-oxopentanoic acid;TETRAPEPTIDE-21 [INCI];DTXCID40164599;CUVSTAMIHSSVKL-UWVGGRQHSA-N;HY-P5232;DA-58447;CS-0863797;GLYCINE, GLYCYL-L-.ALPHA.-GLUTAMYL-L-LYSYL-;Q27251889;(S)-5-(((S)-6-Amino-1-((carboxymethyl)amino)-1-oxohexan-2-yl)amino)-4-(2-aminoacetamido)-5-oxopentanoic acid;

Chemical Name:(4S)-4-[(2-aminoacetyl)amino]-5-[[(2S)-6-amino-1-(carboxymethylamino)-1-oxohexan-2-yl]amino]-5-oxopentanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C15H27N5O7
M.W/Mr.
389.4
Sequence
One Letter Code:GEKG
Three Letter Code:H-Gly-Glu-Lys-Gly-OH
Application
Anti-aging

Mechanism of Action (MOA)

Tetrapeptide-21 is a synthetic signal peptide composed of four amino acids designed to mimic fragments of extracellular matrix proteins. By interacting with skin cells, it is believed to support cellular communication pathways involved in the synthesis of key structural components, such as collagen and fibronectin. This peptide may contribute to optimizing the extracellular matrix environment through biochemical signaling, promoting a favorable milieu for skin's structural protein maintenance.

Tetrapeptide-21 can be incorporated into various cosmetic formulations to support innovative product development.

- Suitable for use in facial serums, creams, and lotions
- Compatible with water-based and emulsion systems
- Can be added during the cooling phase of formulation
- Recommended for daily skincare products targeting the face and neck
- Appropriate for inclusion in under-eye and targeted treatment formulas
- May be combined with other peptides and active ingredients

InChI
InChI=1S/C15H27N5O7/c16-6-2-1-3-9(14(26)18-8-13(24)25)20-15(27)10(4-5-12(22)23)19-11(21)7-17/h9-10H,1-8,16-17H2,(H,18,26)(H,19,21)(H,20,27)(H,22,23)(H,24,25)/t9-,10-/m0/s1
InChI Key
CUVSTAMIHSSVKL-UWVGGRQHSA-N
Canonical SMILES
C(CCN)CC(C(=O)NCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CN
Isomeric SMILES
C(CCN)C[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN

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