Thrombospondin (TSP-1)-derived CD36 binding motif features a defined peptide sequence used to examine receptor-recognition elements. Charged and hydrophobic residues contribute to structured interaction patterns. Researchers investigate its behavior to understand ligand docking and molecular specificity. Applications span structural biology, peptide engineering, and receptor-binding studies.
CAT No: R2641
CAS No:138849-26-0
Synonyms/Alias:Thrombospondin (TSP-1)-derived CD36 binding motif;EX-A9857;HY-P5322;CS-0881184;138849-26-0;
Thrombospondin (TSP-1)-derived CD36 binding motif is a synthetic peptide segment modeled after the functional domain of thrombospondin-1 that interacts specifically with the CD36 receptor. As a specialized bioactive motif, it is widely recognized for its ability to recapitulate the molecular interactions between TSP-1 and CD36, a scavenger receptor implicated in diverse cellular processes. The peptide's structural mimicry of the native binding interface provides researchers with a valuable tool for probing receptor-mediated signaling pathways, cell adhesion dynamics, and extracellular matrix interactions. Its application extends across cell biology, vascular research, and studies of intercellular communication, offering a precise means to dissect the functional consequences of TSP-1/CD36 engagement in a controlled experimental context.
Receptor-Ligand Interaction Studies: The TSP-1-derived CD36 binding motif is extensively utilized to investigate the molecular basis of TSP-1 and CD36 interactions. By providing a defined, reproducible ligand, researchers can elucidate the binding kinetics, specificity, and downstream signaling events triggered by CD36 activation. This approach enables the characterization of receptor function and the identification of critical residues involved in ligand recognition, supporting the development of new hypotheses regarding the regulation of CD36-mediated cellular responses.
Angiogenesis Modulation Research: The peptide motif serves as a powerful tool in studies of angiogenesis, where the TSP-1/CD36 axis plays a central role in the negative regulation of new blood vessel formation. By selectively engaging CD36, the motif allows for the assessment of anti-angiogenic signaling pathways in endothelial cells, including the induction of apoptosis and the inhibition of migration and proliferation. Such investigations are vital for advancing the understanding of vascular homeostasis and for identifying potential molecular checkpoints in the control of neovascularization.
Cell Adhesion and Migration Assays: Researchers employ the TSP-1-derived CD36 binding motif in functional assays to dissect the contribution of CD36 to cell adhesion and motility. The peptide can be used to coat surfaces or as a soluble stimulus, providing a controlled method to analyze how CD36 engagement influences cytoskeletal dynamics, integrin activation, and cell-extracellular matrix interactions. These studies are instrumental in unraveling the mechanisms underlying cell movement and tissue remodeling in both physiological and pathological settings.
Oxidative Stress and Lipid Uptake Studies: The interaction between TSP-1-derived motifs and CD36 has been implicated in the regulation of oxidative stress responses and lipid uptake in various cell types, including macrophages and endothelial cells. By using the synthetic motif, researchers can isolate CD36-dependent pathways that modulate reactive oxygen species production, lipid internalization, and downstream metabolic effects. Such applications are critical for exploring the molecular links between extracellular matrix signals, cellular metabolism, and redox homeostasis.
Signal Transduction Pathway Analysis: The defined sequence of the CD36 binding motif enables detailed dissection of intracellular signaling cascades initiated by receptor engagement. Experimental use of the peptide supports the mapping of phosphorylation events, adaptor protein recruitment, and transcriptional responses following CD36 activation. These analyses provide mechanistic insights into how extracellular cues from TSP-1 are transduced into specific gene expression patterns and cellular behaviors, facilitating the discovery of novel regulatory nodes within the broader context of cell signaling networks.
4. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
5. Myotropic activity of allatostatins in tenebrionid beetles
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More