Tifuvirtide, an exquisitely crafted biomedical marvel, emerges as a robust antiviral peptide, distinctly impacting the therapeutic domain. Its indomitable focus lies in selectively combating the infamous HIV/AIDS menace by impeding the intricate fusion episode of the nefarious virus and thwarting its trespass into unsuspecting host cells.
CAT No: R2031
CAS No:251562-00-2
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-6-aminohexanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-amino-5-oxopentanoyl]amino]-5-amino-5-oxopentanoyl]amino]-5-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-oxopentanoic acid
Tifuvirtide is a synthetic peptide compound designed as an analog of naturally occurring protein segments involved in viral fusion mechanisms. As a member of the peptide inhibitor class, Tifuvirtide is structurally characterized by sequences that mimic regions of viral envelope proteins, enabling it to interact specifically with target biomolecules. Its unique amino acid arrangement confers high affinity for helical domains essential to membrane fusion processes, making it a valuable tool for dissecting molecular interactions at the virus-host interface. The compound's biochemical properties and stability profile have positioned it as a relevant research agent in virology, protein-protein interaction studies, and the development of novel fusion inhibitors.
Antiviral Mechanism Investigation: In virology research, Tifuvirtide serves as a reference compound for elucidating the molecular basis of viral entry inhibition. Its mode of action, which involves binding to heptad repeat regions of viral envelope proteins, allows researchers to study conformational changes required for membrane fusion. By employing this peptide in cell-based assays or biochemical reconstitution systems, scientists can map key residues and structural motifs that dictate fusion competency, thereby advancing fundamental understanding of viral infectivity and resistance mechanisms.
Fusion Inhibitor Screening: The compound is widely used as a positive control or benchmark in high-throughput screening platforms aimed at identifying novel peptide-based or small-molecule fusion inhibitors. Its well-characterized inhibitory profile provides a standard for evaluating the potency and selectivity of candidate molecules targeting similar viral entry pathways. Utilizing Tifuvirtide in comparative assays accelerates the optimization of new inhibitors and supports structure-activity relationship studies critical to antiviral drug discovery pipelines.
Protein-Protein Interaction Studies: Tifuvirtide's defined sequence and binding specificity make it a robust probe for investigating protein-protein interactions, particularly those governing membrane fusion events. Researchers leverage its ability to disrupt or stabilize specific complexes to dissect the energetics and dynamics of transient interactions between viral and host proteins. Such studies are essential for mapping interaction networks and for designing next-generation peptide mimetics with improved biophysical properties.
Peptide Engineering and Design: The structural features of this compound provide a template for the rational design and optimization of synthetic peptides with enhanced stability, solubility, or target affinity. By analyzing its sequence-function relationships, peptide chemists and structural biologists can develop analogs with tailored pharmacokinetic or biophysical characteristics. These efforts inform the creation of new research tools and support advances in peptide-based delivery systems or molecular diagnostics.
Structural Biology Applications: Tifuvirtide is frequently utilized in structural biology workflows as a model system for crystallography, NMR, or cryo-EM studies focused on peptide-protein complexes. Its ability to form stable interactions with viral fusion domains facilitates the elucidation of high-resolution structures, enabling detailed visualization of binding interfaces and conformational transitions. Insights gained from these structural studies inform broader efforts in antiviral research and the rational engineering of fusion-inhibitory peptides.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More