Tos-D-Pro-OH is a D-proline derivative in which the carboxyl group is present as a free carboxylic acid (-CO2H) and the amino functionality is modified by a tosyl (Ts) protecting group, yielding an N-tosylated amino acid with a pyrrolidine ring side chain. The molecule therefore contains a secondary ring nitrogen bearing the sulfonamide (N-SO2-aryl) and retains the stereochemical designation D at the proline center, while presenting both the sulfonamide and carboxyl groups as distinct hydrogen-bonding and acid-base sites. N-tosylated D-proline is commonly used as a protected amino acid building block for controlled peptide coupling and for preparing stereodefined proline-containing peptide or peptidomimetic intermediates, as well as for chemical biology and analytical workflows requiring a stable, derivatized proline scaffold.
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