trans-4-Hydroxy-DL-proline is a hydroxy-substituted proline derivative featuring a pyrrolidine ring with a carboxylic acid and a secondary amine, where the 4-hydroxy substituent is positioned in the trans relationship relative to the ring framework. The molecule exists as a DL mixture at the stereocenters implied by the "DL" designation, and the side-chain hydroxyl provides hydrogen-bonding and polarity that can influence conformational preferences and peptide secondary-structure tendencies when incorporated. As a non-proteinogenic or modified amino acid building block, it is used in peptide synthesis and structure-activity or conformational studies to introduce a hydroxyl-bearing proline residue for chemical biology, biomaterials, and analytical method development.
CAT No: CP01103
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