Urotensin-II (UT) receptor ligand that competitively antagonizes U-II induced contractions in the rat aorta (pIC50 = 7.46) and prevents plasma extravasation elicited by U-II in mice in vivo. Behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays.
CAT No: R1011
CAS No:879497-82-2
Synonyms/Alias:UFP803;879497-82-2;UFP 803 TFA;AKOS024457148;DA-58866;PD079336;(2S)-2-[[(4R,7S,13R,16S)-19-[[(2S)-2-amino-3-carboxypropanoyl]amino]-10-(2-aminoethyl)-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid;
UFP 803 is a synthetic peptide compound designed for advanced biochemical research applications. As a custom-engineered peptide, UFP 803 is notable for its sequence-specific properties and its capacity to interact selectively with biological targets of interest. Its design enables researchers to probe intricate cellular mechanisms, making it a valuable tool in peptide-based studies that require high specificity and functional versatility. The compound's relevance is underscored by its utility in experimental protocols that demand precise modulation of molecular pathways, supporting the ongoing development of peptide science and functional biochemistry.
Receptor modulation studies: UFP 803 is frequently employed in research aiming to elucidate the functional roles of specific cell surface receptors, particularly within the context of G protein-coupled receptor (GPCR) systems. Its tailored sequence allows for the selective activation or inhibition of target receptors, providing researchers with a means to dissect downstream signaling cascades. By enabling precise control over receptor activity, the peptide facilitates investigations into receptor pharmacology, ligand-receptor interactions, and the mapping of signaling networks in cellular models.
Peptide structure-activity relationship analysis: The unique sequence and conformational attributes of UFP 803 make it an exemplary candidate for structure-activity relationship (SAR) studies. Researchers utilize the compound to systematically assess how modifications in peptide structure influence biological function, binding affinity, and specificity. Such analyses are critical for advancing the rational design of novel peptide ligands, optimizing bioactivity, and identifying key structural motifs responsible for target engagement.
Cell signaling pathway elucidation: UFP 803 serves as a powerful tool for dissecting complex intracellular signaling pathways. By acting as a selective modulator, it allows scientists to investigate the consequences of pathway activation or inhibition in various cell types. This approach aids in mapping the molecular events that underlie physiological and pathological processes, contributing to a deeper understanding of signal transduction mechanisms and their regulatory checkpoints.
Peptide-based assay development: The compound's well-defined sequence and functional properties render it suitable for use in developing and validating biochemical assays. UFP 803 can be integrated into binding assays, functional screening platforms, and high-throughput analyses aimed at characterizing receptor-ligand interactions or assessing peptide activity. Its inclusion in assay systems enhances reproducibility and provides a reliable benchmark for comparative studies, supporting the advancement of peptide discovery technologies.
Tool for ligand screening and optimization: In the context of drug discovery and chemical biology, UFP 803 is utilized as a reference ligand or probe in high-content screening campaigns. Its specific activity profile enables the identification and optimization of novel compounds with similar or improved functional characteristics. By serving as a comparator or calibrator, the peptide aids in refining structure-based design strategies and evaluating the efficacy of new molecular entities in research settings.
2. Emu oil in combination with other active ingredients for treating skin imperfections
3. Myotropic activity of allatostatins in tenebrionid beetles
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