Urocortin II, human, a pivotal peptide hormone, assumes a pivotal function within the intricate mechanisms of the human physique. Extensive scrutiny has been devoted to investigating the potential therapeutic utilization of this remarkable product in ameliorating cardiovascular ailments, most notably heart failure and hypertension. Furthermore, Urocortin II, human, exerts its effect as an agonist, specifically targeting receptors, thereby regulating stress-related reactions and fostering cardiovascular equilibrium. With its auspicious capacity, it augments the prospect of novel pharmaceutical advancements in the biomedical sector.
CAT No: R2006
CAS No:351999-18-3
Synonyms/Alias:Urocortin 2;Urocortin II;Urocortin-2;UNII-2IH21SQ983;2IH21SQ983;351999-18-3;
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3R)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid
Urocortin II, human is a synthetic peptide that mirrors the sequence of the endogenous human Urocortin II, a member of the corticotropin-releasing factor (CRF) peptide family. Characterized by its selective affinity for the CRF type 2 receptor (CRF2), this peptide plays a pivotal role in the modulation of stress responses, cardiovascular regulation, and neuroendocrine signaling. Its unique receptor selectivity and structural homology to other CRF-related peptides have positioned it as an important molecular tool for dissecting the physiological and pathophysiological roles of CRF2-mediated pathways in both central and peripheral tissues. Researchers leverage Urocortin II, human to explore mechanisms underlying stress adaptation, cardiovascular homeostasis, and neurobiological processes, making it a valuable asset in peptide-based research.
Receptor pharmacology: As a highly selective agonist for the CRF2 receptor, Urocortin II is routinely employed in studies aimed at elucidating the receptor's ligand-binding characteristics, downstream signaling cascades, and tissue-specific expression profiles. Its use enables precise differentiation between CRF1 and CRF2 receptor-mediated effects, supporting the development of novel ligands, antagonists, or allosteric modulators targeting the CRF system. By providing a reliable means to activate CRF2 without significant off-target activity at CRF1, this peptide supports receptor mapping and functional assays in a variety of cellular and tissue models.
Neuroendocrine research: The peptide's ability to mimic endogenous Urocortin II activity makes it an indispensable tool for investigating neuroendocrine stress responses and hypothalamic-pituitary-adrenal (HPA) axis regulation. Researchers utilize it to probe the influence of CRF2 activation on hormone secretion, neuronal excitability, and synaptic plasticity. Such studies help clarify the distinct roles of CRF family peptides in neuroendocrine adaptation to stress and provide insights into the molecular underpinnings of anxiety, depression, and related neuropsychiatric conditions at the preclinical level.
Cardiovascular studies: Urocortin II's potent vasodilatory and cardioprotective properties, mediated primarily through CRF2 receptors, have made it a focal point in cardiovascular research. It is commonly employed to assess its effects on vascular tone, myocardial contractility, and endothelial function in isolated tissue preparations and in vivo models. By facilitating the exploration of CRF2-dependent signaling in the heart and vasculature, the peptide aids in the identification of novel regulatory mechanisms and potential targets for cardiovascular modulation.
Peptide structure-activity analysis: The defined amino acid sequence and receptor selectivity of Urocortin II, human make it well-suited for structure-activity relationship (SAR) studies within the CRF peptide family. Researchers use it as a template for designing analogs, assessing the impact of specific residue substitutions, and mapping functional domains responsible for receptor interaction and signal transduction. Such investigations advance understanding of peptide-receptor dynamics and inform the rational design of next-generation CRF2-targeted molecules.
Peptide-based assay development: Urocortin II is frequently incorporated into in vitro assay systems designed to quantify CRF2 receptor activation, monitor downstream second messenger responses, or screen for potential modulators of the CRF axis. Its robust and selective activity profile enhances the reliability of pharmacological assays, enabling high-throughput screening and detailed kinetic analyses. This application supports both basic research and early-stage drug discovery efforts focused on neuroendocrine and cardiovascular targets.
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