A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
CAT No: R1954
CAS No:9034-50-8
Synonyms/Alias:Vasotocin; DL-cysteinyl-DL-tyrosyl-DL-isoleucyl-DL-glutaminyl-DL-asparagyl-DL-cysteinyl-DL-prolyl-DL-arginyl-glycinamide (1->6)-disulfide
Chemical Name:1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-butan-2-yl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Vasopressin Acetate is a synthetic peptide analogue of the naturally occurring antidiuretic hormone vasopressin, characterized by its ability to modulate water homeostasis and vascular tone through interaction with specific vasopressin receptors. As a nonapeptide, it plays a pivotal role in the regulation of renal water reabsorption and vascular smooth muscle contraction, making it a compound of significant interest in physiological, pharmacological, and biochemical research. Its well-defined structure and receptor specificity have established it as a valuable tool for probing mechanisms of hormone signaling, receptor-ligand interactions, and downstream cellular responses. The acetate salt form enhances its stability and solubility, further supporting its utility in a variety of experimental contexts where precise modulation of vasopressin pathways is required.
Receptor Pharmacology: Vasopressin Acetate is extensively utilized in studies investigating vasopressin receptor subtype function, particularly V1a, V1b, and V2 receptors expressed in different tissues. Researchers employ the peptide to characterize receptor binding affinities, dissect downstream signaling cascades, and differentiate physiological responses mediated by each receptor class. Such studies are critical for elucidating the fundamental biology of G protein-coupled receptor signaling and for mapping the tissue-specific actions of vasopressin analogues.
Signal Transduction Research: The compound serves as a model agonist in cellular and biochemical assays designed to probe intracellular signaling mechanisms downstream of vasopressin receptor activation. By applying Vasopressin Acetate to cultured cells or tissue preparations, investigators can monitor second messenger generation, such as cyclic AMP or inositol phosphates, and evaluate the activation of protein kinases and other effectors. This facilitates a deeper understanding of hormonal regulation of cellular processes and aids in the identification of novel signaling intermediates.
Renal Physiology Studies: Vasopressin Acetate is a cornerstone in experimental models of water and electrolyte balance, where it is used to mimic endogenous hormone action and assess renal concentrating ability. Researchers leverage its antidiuretic properties to investigate mechanisms of water reabsorption in the collecting ducts, analyze aquaporin channel trafficking, and study the hormonal control of kidney function under varying physiological and pathophysiological conditions. These insights are vital for advancing knowledge in nephrology and systemic osmoregulation.
Vascular Function Analysis: The peptide is employed in vascular biology research to evaluate its effects on smooth muscle contraction and vasomotor regulation. By applying Vasopressin Acetate to isolated vessel preparations or in vitro cell models, scientists can quantify contractile responses, delineate receptor-mediated pathways, and explore the modulation of vascular tone. These applications contribute to a more comprehensive understanding of blood pressure regulation and the interplay between neuroendocrine signals and vascular responsiveness.
Peptide Drug Discovery: Beyond its role as a research tool, Vasopressin Acetate is instrumental in the development and screening of novel peptide-based ligands and small molecule modulators targeting vasopressin receptors. Its well-characterized pharmacological profile makes it suitable as a reference compound in high-throughput screening assays, structure-activity relationship studies, and the validation of new chemical entities. This supports the advancement of next-generation therapeutics and provides a robust platform for translational research in peptide pharmacology.
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