Veldoreotide, a remarkable synthetic somatostatin analog widely employed in the field of biomedicine, emerges as an imperative therapeutic agent bestowed with exquisite properties. Ostensibly tailored to combat acromegaly, an endocrine anomaly resultant from the relentless surge in growth hormone secretion, Veldoreotide orchestrates its profound efficacy through the judicious inhibition of growth hormone release. Through such a meticulously orchestrated mechanism, the subject in question undeniably manifests potential in permeating symptomatic alleviation, targeting the resolution of presumably incapacitating manifestations encompassing the elongation of appendages, including hands and feet, as well as pertinent facial metamorphoses.
CAT No: R1984
CAS No:252845-37-7
Synonyms/Alias:Veldoreotide;Somatoprim;252845-37-7;Veldoreotide [USAN];COR-005;PTR 3173;UNII-1Z83587HBN;1Z83587HBN;VELDOREOTIDE [INN];DG 3173;VELDOREOTIDE [WHO-DD];PTR-3173;DG3173;2-[(3S,6S,9S,12R,15S,18S)-9-(4-Aminobutyl)-3,18-dibenzyl-6-[(1R)-1-hydroxyethyl]-12,15-bis(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,25-octaoxo-1,4,7,10,13,16,19,24-octazacyclooctacos-1-yl]acetamide;DG-3173;veldoreotida;2-[(3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-6-(1-hydroxyethyl)-12,15-bis(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,25-octaoxo-3,18-bis(phenylmethyl)-1,4,7,10,13,16,19,24-octazacyclooctacos-1-yl]acetamide;GLYCINAMIDE, N-(4-AMINO-1-OXOBUTYL)-L-PHENYLALANYL-L-TRYPTOPHYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-L-PHENYLALANYL-N2-(3-CARBOXYPROPYL)-, (7->1)-LACTAM;N4.1-(2-AMINO-2-OXOETHYL)-CYCLO(4-AMINOBUTANOYL-4-AMINOBUTANOYL-L-PHENYLALANYL-L-TRYPTOPHYL-D-TRYPTOPHYL-L-LYSYL-L-THREONYL-L-PHENYLALANYL);veldoreotidum;2-((3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-3,18-dibenzyl-6-((1R)-1-hydroxyethyl)-12,15-bis((1H-indol-3-yl)methyl)-2,5,8,11,14,17,20,25-octaoxo-1,4,7,10,13,16,19,24-octaazacyclooctacosan-1-yl)acetamide;2-((3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-6-(1-hydroxyethyl)-12,15-bis(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,25-octaoxo-3,18-bis(phenylmethyl)-1,4,7,10,13,16,19,24-octazacyclooctacos-1-yl)acetamide;2-[(3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-3,18-dibenzyl-6-[(1R)-1-hydroxyethyl]-12,15-bis[(1H-indol-3-yl)methyl]-2,5,8,11,14,17,20,25-octaoxo-1,4,7,10,13,16,19,24-octaazacyclooctacosan-1-yl]acetamide;GTPL8487;GLXC-20851;EX-A7913;HY-P0024;DB12777;DA-78857;CS-0012831;Q27253298;
Chemical Name:2-[(3S,6S,9S,12R,15S,18S)-9-(4-aminobutyl)-3,18-dibenzyl-6-[(1R)-1-hydroxyethyl]-12,15-bis(1H-indol-3-ylmethyl)-2,5,8,11,14,17,20,25-octaoxo-1,4,7,10,13,16,19,24-octazacyclooctacos-1-yl]acetamide
Veldoreotide is a synthetic peptide analog designed to mimic and enhance the physiological actions of native somatostatin. Structurally characterized as a cyclic peptide, it exhibits high affinity for multiple somatostatin receptor subtypes, particularly SSTR2 and SSTR5, making it a valuable molecular tool in neuroendocrine research. Its resistance to enzymatic degradation and improved receptor selectivity enable robust investigation of somatostatin-mediated signaling pathways. Veldoreotide's unique profile positions it as an important reagent for researchers exploring peptide-receptor interactions, intracellular signaling cascades, and the modulation of hormone secretion in various experimental models.
Receptor binding studies: Veldoreotide is widely employed in receptor pharmacology to elucidate the binding dynamics and selectivity of somatostatin analogs. Its defined interaction with somatostatin receptor subtypes allows for precise mapping of ligand-receptor affinities using radioligand binding assays, surface plasmon resonance, or fluorescence-based techniques. Researchers utilize these studies to characterize receptor subtype specificity, affinity constants, and competitive binding profiles, which are critical for understanding the molecular determinants of peptide-receptor recognition and for guiding the rational design of next-generation analogs.
Signal transduction research: The peptide serves as a robust probe for dissecting the downstream signaling events triggered by somatostatin receptor activation. By applying veldoreotide to cultured cells or tissue preparations, investigators can monitor the modulation of intracellular second messengers such as cyclic AMP, calcium flux, and protein phosphorylation states. These experiments provide key insights into the regulatory mechanisms by which somatostatin analogs influence cellular proliferation, hormone release, and neuroendocrine feedback loops, supporting the broader study of G protein-coupled receptor (GPCR) biology.
Peptide structure-activity relationship (SAR) analysis: Veldoreotide's well-defined primary and tertiary structure makes it an exemplary model for SAR investigations within the somatostatin analog family. Researchers leverage this compound to systematically evaluate how specific amino acid substitutions, conformational constraints, or cyclization motifs affect biological activity and receptor selectivity. Such SAR analyses inform the optimization of peptide therapeutics, aid in the development of novel analogs with tailored functional profiles, and contribute to the fundamental understanding of peptide-receptor interactions.
Endocrine secretion assays: The compound is frequently utilized in in vitro and ex vivo systems to study the regulation of hormone secretion from neuroendocrine and endocrine cells. By modulating somatostatin receptor activity, veldoreotide enables detailed examination of its inhibitory effects on the release of hormones such as growth hormone, insulin, and glucagon. These assays are essential for unraveling the complex feedback mechanisms governing endocrine homeostasis, as well as for validating the functional consequences of receptor engagement in physiologically relevant contexts.
Peptide stability and degradation studies: Owing to its engineered resistance to proteolytic enzymes, veldoreotide is an important standard in evaluating peptide stability under various experimental conditions. Researchers assess its metabolic fate in plasma, tissue homogenates, or cell culture media to benchmark the degradation kinetics of novel analogs. Such studies are crucial for understanding the factors influencing peptide half-life, bioavailability, and suitability for further development in research and industrial applications.
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