Z-D-Arg(Z)2-OSu is a protected, D-stereochemically specified arginine derivative in which the α-amino group is protected by a benzyloxycarbonyl (Z/Cbz-type) group and the side-chain guanidinium functionality is masked as two Z-protected moieties, forming a bis-Z protected arginine analogue. The molecule also contains a carboxylate activated as an N-hydroxysuccinimide ester (OSu), while retaining the ester-linked carbonyl as the reactive electrophilic center for acyl transfer chemistry. In peptide synthesis and peptide coupling workflows, this activated amino acid derivative functions as an acylating reagent that supports formation of peptide bonds to nucleophiles under conditions compatible with the Z protecting groups, and it can be used in chemical biology contexts where controlled installation of a protected arginine residue is required.
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