Z-L-Glu(tBu)-OSu is a protected glutamic acid derivative in which the α-amino group is carbobenzyloxy (Z/Cbz) protected and the α-carboxyl functionality is converted to an N-hydroxysuccinimide ester (OSu), with the side chain retaining the γ-carboxyl group masked as a tert-butyl (tBu) ester. The molecule therefore bears a Z-protected amino group and an OSu-activated carboxyl group that can undergo acyl transfer chemistry, while the tert-butyl ester provides temporary protection for the glutamate side-chain carboxyl during peptide-coupling workflows. Z-L-Glu(tBu)-OSu is used as an amino-acid coupling intermediate for preparing glutamate-containing peptides and related amide linkages, and its OSu activation supports incorporation of the protected glutamate unit under conditions where chemoselective acylation is required.
CAT No: CP25854
CAS No:4666-16-4
Synonyms/Alias:Z-Glu(OtBu)-OSu;4666-16-4;Z-L-glutamicacid5-tert-butyl-1-(N-succinimidyl)ester;5-O-tert-butyl1-O-(2,5-dioxopyrrolidin-1-yl)(2S)-2-(phenylmethoxycarbonylamino)pentanedioate;1-tert-butyl2,5-dioxopyrrolidin-1-yl(4S)-4-{[(benzyloxy)carbonyl]amino}pentanedioate;EINECS225-111-3;AmbotzZAA1222;AC1L32DM;SCHEMBL2777934;96131_FLUKA;CTK8G3825;MolPort-003-939-935;7906AH;ZINC100012293;AM002883;K-9092;3B3-062462;N-Cbz-|A-t-butyl-L-glutamicacidN-hydroxysuccinimideester;N-Cbz-gamma-t-butyl-L-glutamicacidN-hydroxysuccinimideester;5-tert-Butyl1-(2,5-dioxopyrrolidin-1-yl)(S)-2-(((phenylmethoxy)carbonyl)amino)glutarate;(S)-5-[(2,5-Dioxopyrrolidin-1-yl)oxy]-5-oxo-4-[[(benzyloxy)carbonyl]amino]pentanoicacidtert-butylester
Chemical Name:N-alpha-Benzyloxycarbonyl-L-glutamic acid alpha-succinimidyl gamma-t-butyl ester
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