Z-L-Leu-ONp

Name: Z-L-Leu-ONp
Brand: Creative Peptides
Rating: 5 (1 reviews)

Z-L-Leu-ONp is a protected amino acid derivative based on L-leucine in which the α-amino group is carbobenzyloxy (Z, benzyloxycarbonyl) protected and the carboxyl group is converted to a p-nitrophenyl (ONp) ester. The molecule therefore contains a Z-protected amino functionality and an esterified carboxyl group bearing the p-nitrophenoxy leaving group, with the side chain characteristic of leucine (isobutyl) providing hydrophobic functionality. Z-L-Leu-ONp is used as an activated amino acid ester building block in peptide coupling workflows and as a substrate for studying ester reactivity or p-nitrophenyl ester behavior under conditions that promote aminolysis or acyl transfer.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP25469

CAS No:1738-87-0

Synonyms/Alias:1738-87-0;(S)-4-Nitrophenyl2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate;Z-Leu-ONp;Carbobenzoxy-L-leucinep-nitrophenylester;Z-L-leucine4-nitrophenylester;ST51037721;AC1L3YY9;AC1Q60ZR;Z-L-Leu-(p-Nitrophenyl)OH;96742_ALDRICH;SCHEMBL3881009;CHEMBL3278842;96742_FLUKA;CTK8B8726;MolPort-003-939-965;UALXQWNUXKECJD-SFHVURJKSA-N;ZINC2571403;EINECS217-098-8;8981AA;ANW-61129;AR-1I1772;AK-60173;KB-211566;TC-149874;FT-0633811

Chemical Name:N-alpha-Benzyloxycarbonyl-L-leucine p-nitrophenyl ester

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C20H22N2O6

M.W/Mr.

386,39 g/mole

Size

5 g;25 g;

InChI

1S/C20H22N2O6/c1-14(2)12-18(21-20(24)27-13-15-6-4-3-5-7-15)19(23)28-17-10-8-16(9-11-17)22(25)26/h3-11,14,18H,12-13H2,1-2H3,(H,21,24)/t18-/m0/s1

InChI Key

UALXQWNUXKECJD-SFHVURJKSA-N

Canonical SMILES

CC(C)CC(C(=O)OC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)OCC2=CC=CC=C2

1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

2. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

3. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

4. Implications of ligand-receptor binding kinetics on GLP-1R signalling

5. The spatiotemporal control of signalling and trafficking of the GLP-1R

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