Z-L-Pyroglutamic acid is a protected, cyclic amino acid derivative featuring the pyroglutamate (2-pyrrolidone-5-carboxylic acid) ring system with an L-stereochemical designation and a benzyloxycarbonyl (Z, Cbz) protecting group on the amino functionality. The molecule contains a carboxylic acid group and a lactam carbonyl within the five-membered ring, while the Z group masks the amino moiety to control chemoselectivity during peptide-coupling steps and suppress side reactions such as undesired amide formation at the free amine. Z-L-Pyroglutamic acid is used as a building block for preparing pyroglutamyl-containing peptides and peptide intermediates in solution-phase or solid-phase peptide synthesis, where the protected amino group supports stepwise assembly and subsequent deprotection strategies.
CAT No: CP23104
CAS No:32159-21-0
Synonyms/Alias:Z-PYR-OH;32159-21-0;Cbz-L-pyroglutamicacid;Z-L-pyroglutamicacid;(S)-5-Oxo-pyrrolidine-1,2-dicarboxylicacid1-benzylester;SBB058136;(S)-1-(benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylicacid;(S)-1-((Benzyloxy)carbonyl)-5-oxopyrrolidine-2-carboxylicacid;(2S)-5-oxo-1-[benzyloxycarbonyl]pyrrolidine-2-carboxylicacid;(S)-L-(Benzyloxycarbonyl)-5-Oxopyrrolidine-2-CarboxylicAcid;AmbotzZAA1244;AC1LCUOH;PubChem18625;N-Cbz-L-pyroglutamicAcid;C5761_SIGMA;SCHEMBL3845188;CTK7I3241;ZINC57264;MolPort-000-005-178;VHSFUGXCSGOKJX-JTQLQIEISA-N;N-Carbobenzoxy-L-pyroglutamicAcid;Benzyloxycarbonyl-L-pyroglutamicacid;CZ-005;MFCD00037352;AKOS015888232
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