Z-L-Pyroglutamic acid is a protected, cyclic amino acid derivative featuring the pyroglutamate (2-pyrrolidone-5-carboxylic acid) ring system with an L-stereochemical designation and a benzyloxycarbonyl (Z, Cbz) protecting group on the amino functionality. The molecule contains a carboxylic acid group and a lactam carbonyl within the five-membered ring, while the Z group masks the amino moiety to control chemoselectivity during peptide-coupling steps and suppress side reactions such as undesired amide formation at the free amine. Z-L-Pyroglutamic acid is used as a building block for preparing pyroglutamyl-containing peptides and peptide intermediates in solution-phase or solid-phase peptide synthesis, where the protected amino group supports stepwise assembly and subsequent deprotection strategies.
CAT No: CP23104
CAS No:32159-21-0
Synonyms/Alias:Z-PYR-OH;32159-21-0;Cbz-L-pyroglutamicacid;Z-L-pyroglutamicacid;(S)-5-Oxo-pyrrolidine-1,2-dicarboxylicacid1-benzylester;SBB058136;(S)-1-(benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylicacid;(S)-1-((Benzyloxy)carbonyl)-5-oxopyrrolidine-2-carboxylicacid;(2S)-5-oxo-1-[benzyloxycarbonyl]pyrrolidine-2-carboxylicacid;(S)-L-(Benzyloxycarbonyl)-5-Oxopyrrolidine-2-CarboxylicAcid;AmbotzZAA1244;AC1LCUOH;PubChem18625;N-Cbz-L-pyroglutamicAcid;C5761_SIGMA;SCHEMBL3845188;CTK7I3241;ZINC57264;MolPort-000-005-178;VHSFUGXCSGOKJX-JTQLQIEISA-N;N-Carbobenzoxy-L-pyroglutamicAcid;Benzyloxycarbonyl-L-pyroglutamicacid;CZ-005;MFCD00037352;AKOS015888232
3. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
4. TMEM16F and dynamins control expansive plasma membrane reservoirs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More