Z-L-Tyr(tBu)-OSu is a protected amino acid derivative in which L-tyrosine bears a tert-butyl-protected phenolic side chain and the α-amino group is masked as a benzyloxycarbonyl (Z) carbamate, while the carboxyl terminus is converted to an N-hydroxysuccinimide (OSu) ester. The molecule therefore contains a phenolic oxygen protected as a tert-butyl ether, a carbamate-protected amino group, and an activated OSu ester that can undergo acyl transfer to form amide bonds under appropriate conditions. Z-L-Tyr(tBu)-OSu is used as an amino-acid-based coupling reagent and peptide-synthesis intermediate for introducing a tyrosine residue bearing the tBu side-chain protection, and it can also serve as a defined tyrosine handle for chemical conjugation and labeling workflows that require controlled acylation.
CAT No: CP25106
CAS No:10068-67-4
Synonyms/Alias:Z-Tyr(tBu)-OSu;10068-67-4;AmbotzZAA1255;MolPort-008-269-466;0247AA;ZINC71788214;AKOS016003320;AK-81344;KB-281501;K-0185;2,5-Dioxo-1-pyrrolidinylN-[(benzyloxy)carbonyl]-O-(2-methyl-2-propanyl)-L-tyrosinate;1-[(S)-3-[4-(1,1-Dimethylethoxy)phenyl]-1-oxo-2-[[(benzyloxy)carbonyl]amino]propoxy]-2,5-pyrrolidinedione
Chemical Name:N-alpha-Benzyloxycarbonyl-O-t-butyl-L-tyrosine succinimidyl ester
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