An excellent fluorogenic substrate for measuring the peptidylglutamyl-peptide-hydrolyzing (PGPH) activity of the 20S proteasome, which is excited at 340-360 nm and emits at 440-460 nm. It is typically used in cell lysates after experimental treatment.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | Z-Leu-Leu-Glu-AMC;348086-66-8;Z-LLE-AMC;Cbz-Leu-Leu-Glu-AMC;(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid;(4S)-4-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-5-[(4-methyl-2-oxochromen-7-yl)amino]-5-oxopentanoic acid;Z-Leu-Leu-Glu-MCA;Z-Leu-Leu-Glu-7-Amino-4-Methylcoumarin;Z-Leu-Leu-Glu-AMC [Z-LLE-AMC];MFCD01074989;Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN;Z-L-Leu-L-Leu-L-Glu-AMC;SCHEMBL15569405;CHEBI:229563;AKOS027327743;Proteasome Substrate II (Fluorogenic);NCGC00485335-01;FL110601;HY-123053;CS-0081090;Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, >=95%, solid;(4S)-4-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-4-METHYLPENTANAMIDO]-4-METHYLPENTANAMIDO]-4-[(4-METHYL-2-OXOCHROMEN-7-YL)CARBAMOYL]BUTANOIC ACID;(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oicacid;N-[(benzyloxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-alpha-glutamine; |
M.F/Formula | C35H44N4O9 |
M.W/Mr. | 664.7 |
Sequence | One Letter Code:LLE Three Letter Code:Cbz-Leu-Leu-Glu-AMC |
Appearance | Solid lyophilized powder |
Purity | >95% |
Source# | Synthetic |
Long-term Storage Conditions | Soluble in DMSO |
InChI | InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1 |
InChI Key | FOYHOBVZPWIGJM-KCHLEUMXSA-N |
Isomeric SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC3=CC=CC=C3 |
BoilingPoint | 967.8±65.0 °C at 760 mmHg |
Melting Point | N/A |
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
5. TMEM16F and dynamins control expansive plasma membrane reservoirs
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