Z-O-tert.butyl-L-serine N-carboxyanhydride is a protected amino acid N-carboxyanhydride (NCA) derived from L-serine, bearing a Z-type O-protecting group on the hydroxymethyl side chain and a tert-butyl ester/ether protection motif that modulates serine reactivity during polymerization or peptide assembly. The NCA functional group contains the activated carbonyls characteristic of carboxyanhydrides, while the molecule retains the serine backbone framework with the side-chain hydroxyl masked by the specified protecting groups, controlling chemoselectivity toward side-chain functionalization. As an NCA precursor, it is employed in peptide-related synthesis and polymer chemistry to generate serine-containing peptide segments or polypeptide chains under conditions that open the carboxyanhydride ring, enabling stepwise incorporation of the protected serine residue into larger amide frameworks.
CAT No: CP01834
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