Ac-FLTD-CMK

Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1, caspases-4, caspases-5, and caspases-11 , but not the apoptotic caspases such as caspase-3.

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CAT No: OPO-005

CAS No: 2376255-48-8

Synonyms/Alias: Ac-FLTD-CMK;2376255-48-8;(3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid;(4S,7S,10S,13S)-4-Benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid;starbld0009421;Ac-FLTD-CMK?;AKOS040755475;AT34795;DA-60736;MS-30287;HY-111675;CS-0089824;

Chemical Name: (3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC26H37ClN4O8
M.W/Mr.569
SequenceOne Letter Code:FLTD
Three Letter Code:Ac-Phe-Leu-Thr-Asp-CH2Cl
InChIInChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1
InChI KeyUCWNTWGHVCSMJP-WPUDHWPRSA-N
Canonical SMILESCC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=CC=C1)NC(=O)C
Isomeric SMILESC[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CCl)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C)O

1. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

2. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry

3. Implications of ligand-receptor binding kinetics on GLP-1R signalling

4. TMEM16F and dynamins control expansive plasma membrane reservoirs

5. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

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