Acetyl Hexapeptide-49

Acetyl Hexapeptide-49 is a synthetic peptide designed for use in cosmetic formulations targeting sensitive or reactive skin. It supports skin comfort by helping to maintain the skin's natural barrier function and promoting a balanced appearance. Suitable for a range of leave-on products, Acetyl Hexapeptide-49 can be incorporated into emulsions, serums, and gels, aligning with regulatory requirements for global cosmetic applications.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CPC1670

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C40H47N7O6
M.W/Mr.
738.02
Functions
Acetyl Hexapeptide-49 solution ameliorates the discomfort of nagging pain and itch occurring in sensitive skin as a result of PAR-2-induced release of pro-inflammatory mediators, besides restoring the damaged barrier integrity. In very dry sensitive skin, it increases hydration as well as improves scaling, smoothness and softness.

Mechanism of Action (MOA)

Acetyl Hexapeptide-49 is a synthetic signal peptide designed to interact with skin cell receptors involved in the modulation of neurogenic communication pathways. By mimicking a specific sequence within natural skin peptides, it is suggested to influence the release of signaling molecules from sensory nerve endings. This action may help support the skin's response to external stimuli by modulating cellular communication processes associated with skin comfort and barrier function.

Acetyl Hexapeptide-49 is suitable for incorporation into a variety of topical cosmetic formulations.

- Facial serums for daily skincare routines
- Lightweight emulsions such as lotions and creams
- Sheet masks and leave-on gel masks
- Eye contour products
- After-sun or post-procedure soothing products
- Formulations designed for sensitive skin types

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Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.

From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.

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