ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
CAT No: R1158
CAS No:67224-41-3
Synonyms/Alias:Acth (4-11);67224-41-3;N2-(N-(N-(N2-(N-(N-(N-L-Methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycyl)-L-lysine;(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]hexanoic acid;HY-P1503;CS-0044594;Methionyl-glutamyl-histidinyl-phenylalanyl-argininyl-tryptophanyl-glycinyl-lysine;
ACTH 4-11, also known as Adrenocorticotropic Hormone fragment 4-11, is a synthetic peptide corresponding to residues 4 through 11 of the full-length ACTH polypeptide. As a truncated segment of ACTH, this peptide retains a portion of the sequence implicated in neuropeptide signaling and stress response pathways, making it a valuable tool for probing the structure-function relationships within the melanocortin family. Its unique biochemical profile allows researchers to dissect the roles of specific peptide fragments in receptor interactions, signal transduction, and downstream physiological effects, thereby supporting a range of investigations in endocrinology, neurobiology, and peptide pharmacology.
Receptor Binding Studies: ACTH 4-11 is frequently utilized in receptor binding assays to elucidate the minimal sequence requirements for interaction with melanocortin receptors, particularly MC2R and related subtypes. By comparing the binding affinities and activation profiles of this fragment with longer or full-length ACTH peptides, scientists can map critical contact points and functional domains necessary for receptor specificity. Such studies are instrumental in advancing the understanding of peptide-receptor dynamics and in guiding the rational design of novel ligands or antagonists targeting the melanocortin system.
Signal Transduction Research: The peptide fragment serves as a model substrate for investigating intracellular signaling cascades triggered by ACTH-derived sequences. In cellular models expressing melanocortin receptors, the application of ACTH 4-11 allows researchers to monitor downstream events such as cAMP accumulation, protein kinase activation, and gene expression changes. These experiments help delineate the contributions of specific ACTH regions to signal initiation and propagation, providing insights into the molecular mechanisms underlying stress adaptation, adrenal steroidogenesis, and neuroendocrine regulation.
Neuropeptide Function Analysis: ACTH 4-11 is employed in studies exploring the broader physiological and behavioral roles of ACTH-derived peptides within the central nervous system. By administering this fragment in in vitro or ex vivo preparations, researchers can assess its impact on neuronal excitability, neurotransmitter release, or synaptic plasticity. Such investigations are crucial for unraveling the complex interplay between peptide signaling and neural circuit modulation, contributing to a deeper understanding of stress-related neurobiology and the functional diversity of neuropeptides.
Peptide Structure-Activity Relationship (SAR) Studies: The defined sequence of ACTH 4-11 makes it an ideal candidate for systematic structure-activity relationship analyses. Researchers can modify specific amino acid residues within the fragment or compare its activity to that of other ACTH-derived peptides to identify determinants of biological function. These SAR studies are essential for optimizing peptide analogs with tailored receptor selectivity, enhanced stability, or altered bioactivity, thereby informing the development of peptide-based research tools and molecular probes.
Peptide Synthesis and Analytical Method Development: As a well-characterized synthetic peptide, ACTH 4-11 is widely used as a reference standard or calibration compound in peptide synthesis workflows and analytical method validation. Its application in high-performance liquid chromatography (HPLC), mass spectrometry, and other analytical platforms supports the accurate quantification, purity assessment, and structural verification of peptides. This utility is particularly valuable in quality control processes and in the establishment of robust methodologies for peptide research and production.
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