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(Ala11,D-Leu15)-Orexin B (human)

(Ala11,D-Leu15)-Orexin B (human) features alanine and D-leucine substitutions that refine receptor binding and stability. These modifications help probe the structural requirements for orexin receptor interactions. The peptide's altered sequence is used to study appetite regulation and neuropeptide signaling. Researchers apply it to map receptor-binding profiles and functional consequences in neuropeptide-mediated pathways.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(Ala11,D-Leu15)-Orexin B (human)(CAS 532932-99-3)

CAT No: O02005

CAS No:532932-99-3

Synonyms/Alias:[Ala11,D-Leu15]-Orexin B;532932-99-3;(Ala11,d-leu15)-orexin b(human);[Ala11,D-Leu15]-Orexin B TFA;C120H206N44O35S;HB3407;DA-48928;FA109685;[Ala11,D-Leu15]-Orexin B (human) acetate;(Ala11,D-Leu15)-Orexin B (human) trifluoroacetate salt;RSGPPGLQGRAQRLLQASGNHAAGILTM (modifications: Met-28 = C-terminal amide);H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2; H-RSGPPGLQG RAQRL(dL)QASGNHAAGILTM-NH2;

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
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M.F/Formula
C120H206N44O35S
M.W/Mr.
2857.3
Sequence
One Letter Code:RSGPPGLQGRAQRLLQASGNHAAGILTM
Three Letter Code:H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
InChI
InChI=1S/C120H206N44O35S/c1-17-60(10)93(115(197)158-77(44-59(8)9)113(195)162-94(65(15)167)116(198)150-68(95(126)177)34-40-200-16)161-91(175)51-137-96(178)61(11)143-97(179)62(12)146-108(190)78(45-66-47-133-55-142-66)157-112(194)79(46-87(125)171)149-89(173)49-139-102(184)80(53-165)159-99(181)64(14)145-105(187)72(29-32-85(123)169)154-110(192)75(42-57(4)5)156-111(193)76(43-58(6)7)155-106(188)70(25-20-37-136-120(131)132)152-107(189)73(30-33-86(124)170)151-98(180)63(13)144-104(186)69(24-19-36-135-119(129)130)147-88(172)48-138-101(183)71(28-31-84(122)168)153-109(191)74(41-56(2)3)148-90(174)50-140-114(196)82-26-21-39-164(82)117(199)83-27-22-38-163(83)92(176)52-141-103(185)81(54-166)160-100(182)67(121)23-18-35-134-118(127)128/h47,55-65,67-83,93-94,165-167H,17-46,48-54,121H2,1-16H3,(H2,122,168)(H2,123,169)(H2,124,170)(H2,125,171)(H2,126,177)(H,133,142)(H,137,178)(H,138,183)(H,139,184)(H,140,196)(H,141,185)(H,143,179)(H,144,186)(H,145,187)(H,146,190)(H,147,172)(H,148,174)(H,149,173)(H,150,198)(H,151,180)(H,152,189)(H,153,191)(H,154,192)(H,155,188)(H,156,193)(H,157,194)(H,158,197)(H,159,181)(H,160,182)(H,161,175)(H,162,195)(H4,127,128,134)(H4,129,130,135)(H4,131,132,136)/t60-,61-,62-,63-,64-,65+,67-,68-,69-,70-,71-,72-,73-,74-,75+,76-,77-,78-,79-,80-,81-,82-,83-,93-,94-/m0/s1
InChI Key
SURUUKNICBOUOQ-UBNRXWOCSA-N

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