Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt is a protected, naturally occurring amino acid derivative in which L-phenylalanine bears an allyloxycarbonyl (Alloc) protecting group on the amino functionality, and the resulting zwitterionic form is paired with dicyclohexylamine to form a salt. The molecule contains a free carboxylic acid group and an Alloc-protected amino group, with the phenyl side chain providing a hydrophobic aromatic functionality while the stereochemistry corresponds to the L-configuration indicated in the name. As a protected amino acid salt, it is used as a precursor for stepwise peptide synthesis and for preparing peptide intermediates where the Alloc group provides chemoselective control of the amino reactivity during coupling and subsequent deprotection strategies.
CAT No: CP01607
Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt is a protected L-phenylalanine building block featuring an allyloxycarbonyl (Alloc) group on the amino functionality, paired as a dicyclohexylamine salt to support handling and consistent reagent performance. The phenylalanine side chain provides the hydrophobic aromatic character commonly used in peptide sequence design, while the Alloc protection enables orthogonal deprotection strategies that are frequently leveraged in peptide synthesis workflows requiring controlled unveiling of the N-terminus. This protected amino acid derivative is therefore selected when robust coupling and later selective functional-group removal are needed during assembly of defined peptide intermediates.
1. Orthogonal Peptide Synthesis
Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt is used by peptide chemists to incorporate an Alloc-protected L-phenylalanine residue into peptide chains where orthogonal protecting-group logic is required. The Alloc group supports downstream strategies that separate N-deprotection timing from other protecting-group manipulations, which is particularly valuable in stepwise preparation of peptide segments and in workflows that demand precise control over which amine is available for coupling at each stage. Researchers developing protected peptide intermediates for custom peptide synthesis and peptide library construction often select this salt form to improve practical reagent handling during repeated coupling cycles.
2. Segment Coupling Building Block
Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt is frequently employed as a defined amino acid building block for segment condensation and solution-phase peptide assembly, where consistency of the protected residue is critical to achieving reproducible coupling outcomes across multiple batches. The combination of an aromatic phenylalanine side chain and an Alloc-protected amino group makes it a common choice for constructing hydrophobic peptide motifs and for positioning phenylalanine at specific sequence locations in larger synthetic targets. Pharmaceutical intermediate development groups and contract peptide manufacturing teams use such protected residues to standardize intermediate quality and to streamline the preparation of next-step coupling partners.
3. Peptide Library And SAR Intermediates
Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt supports medicinal chemistry programs that generate peptide-based structure-activity relationship (SAR) series, especially when phenylalanine-containing analogs must be synthesized with controlled protection patterns. By providing a stable, protected form of L-phenylalanine, it enables parallel synthesis of closely related peptide analogs where the timing of N-deprotection and subsequent derivatization must be coordinated with other functional groups present in the sequence. This reagent is therefore used by researchers building defined peptide intermediates for analog screening, allowing systematic variation of peptide composition while maintaining a reliable synthetic handle for later transformations.
4. Protected Amino Acid Intermediate Supply
Allyloxycarbonyl-L-Phenylalanine dicyclohexylamine salt is also used as a practical protected amino acid intermediate in custom synthesis workflows that require reliable sourcing of Alloc-protected phenylalanine for downstream derivatization. Chemical development teams and specialty synthesis laboratories rely on such protected building blocks to reduce variability in intermediate preparation and to ensure that the protected residue can be carried through multi-step sequences without premature exposure of the amine functionality. In this context, the dicyclohexylamine salt form is selected to support reproducible handling in routine peptide chemistry operations, helping maintain consistent performance when preparing a range of protected peptide fragments.
1. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
2. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More