1-Amino-4-chloro-2-butyne · HCl

1-Amino-4-chloro-2-butyne · HCl is a chloroalkyne amino building block supplied as a hydrochloride salt, providing a stabilized, water-compatible amine for downstream derivatization. Its terminal alkyne and secondary chloro-functional handle make it attractive for constructing alkyne-containing intermediates and for introducing amino functionality into medicinal chemistry and chemical biology workflows where controlled reactivity is required.

1. Alkynyl Intermediate Synthesis

1-Amino-4-chloro-2-butyne · HCl is used to build alkynyl-containing pharmaceutical intermediates and specialty organic compounds in research and industrial synthesis. The presence of both an amine and an alkyne allows chemists to sequence functional group transformations around a single core scaffold, supporting the preparation of alkyne-bearing linkers, side-chain analogs, and coupling-ready fragments used in small-molecule discovery programs and process development.

2. Medicinal Chemistry Fragment Assembly

1-Amino-4-chloro-2-butyne · HCl serves as a practical scaffold for assembling reactive fragments in medicinal chemistry, particularly when an alkyne motif is needed for subsequent coupling, cycloaddition, or structure-activity relationship (SAR) exploration. Developers commonly incorporate this type of amino-chloroalkyne intermediate into libraries of analogs where the terminal alkyne provides a handle for modular diversification, while the chloro substituent supports further substitution chemistry to tune substitution patterns.

3. Click-Style Conjugation Building Block

1-Amino-4-chloro-2-butyne · HCl is frequently selected as an alkyne precursor for conjugation strategies that rely on terminal alkyne reactivity, enabling the preparation of alkyne-functional biomolecule derivatives and polymer linkers. In chemical biology and materials research settings, the hydrochloride salt form helps manage amine handling during labeling workflows, while the terminal alkyne supports downstream attachment to azide-functional partners to generate defined conjugates for assay development and surface or bulk material functionalization.

4. Pharmaceutical Process Intermediate

1-Amino-4-chloro-2-butyne · HCl is also used as a pharmaceutical intermediate building block where robust, isolable reactivity is valued for multistep synthesis planning. Process chemists leverage the dual functional-group identity (amine and chloroalkyne) to streamline intermediate staging toward final alkyne-containing targets, including intermediates used for scale-up route scouting and for producing defined, chemically characterized precursors for further manufacturing steps.

1. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

2. Investigating Potential Interactions Between Neurohypophyseal Peptides, their Drug Analogs, and Coagulation Factor VIII

3. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

4. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review

5. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes