BA46; Lactadherin
BA46 (97-106) is a synthetic peptide fragment corresponding to amino acid residues 97 through 106 of the BA46 protein sequence. As a peptide compound, it represents a defined segment of a larger protein, providing a valuable tool for probing protein structure, function, and interactions in biochemical research. Its precise sequence enables targeted studies of epitope mapping, molecular recognition, and post-translational modification analysis, making it particularly relevant in fields such as immunology, cancer research, and protein engineering. The ability to synthesize and manipulate such defined peptide fragments allows researchers to dissect the roles of specific protein regions, gaining insights into biological mechanisms and molecular pathways.
Epitope mapping: Researchers frequently use BA46 (97-106) as a defined epitope for antibody characterization and mapping studies. By providing a specific segment of the BA46 protein, this peptide enables detailed investigation of antibody binding sites, facilitating the identification and validation of monoclonal or polyclonal antibodies with specificity for the BA46 protein. Such studies are crucial in immunodiagnostics, biomarker discovery, and the development of research-grade detection reagents, as they allow precise determination of antigenic determinants and support the generation of high-affinity, targeted antibodies.
Protein-protein interaction studies: The BA46 (97-106) peptide serves as a valuable probe for examining molecular interactions involving the BA46 protein. By incorporating the peptide into binding assays or affinity chromatography workflows, researchers can assess the binding properties of candidate proteins, receptors, or signaling molecules that interact with this protein region. Such studies help elucidate the molecular mechanisms underlying BA46-mediated pathways and can reveal novel interaction partners, enhancing understanding of the protein's biological roles in cellular processes.
Post-translational modification analysis: Synthetic peptides like BA46 (97-106) are often used as substrates or standards in studies of post-translational modifications, such as phosphorylation, acetylation, or methylation. The defined sequence allows researchers to investigate the susceptibility of specific residues within the BA46 region to enzymatic modification, supporting the identification of modification sites and the assessment of functional consequences. This approach provides a controlled system for dissecting regulatory mechanisms that influence protein activity, localization, or stability.
Immunogenicity and vaccine research: BA46 (97-106) can be utilized in preclinical immunogenicity studies to evaluate the potential of specific protein regions to elicit immune responses. By using the peptide in in vitro assays or animal models, researchers can assess T-cell or B-cell reactivity, informing the design of peptide-based antigens or immunogens for research purposes. Such studies contribute to the broader understanding of immune recognition and the development of research tools for immunological investigations.
Analytical assay development: The defined nature of the BA46 (97-106) peptide makes it a useful standard or calibrator in quantitative analytical assays, such as mass spectrometry-based proteomics or enzyme-linked immunosorbent assays (ELISA). By incorporating the peptide as a reference, laboratories can achieve accurate quantification of the corresponding protein region in complex biological samples, improving assay sensitivity and specificity. This application is particularly valuable for biomarker validation, protein expression analysis, and quality control in peptide-based research workflows.
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