Bradykinin potentiator B contains a peptide framework with enriched proline and aromatic residues that affect flexibility and binding. Its structure enables exploration of peptide-protein interactions and sequence-driven recognition. Researchers study its conformational states across solvents. Applications include motif-function evaluation, peptide engineering, and biophysical analysis.
CAT No: R2466
CAS No:30892-86-5
Synonyms/Alias:Bradykinin potentiator B;30892-86-5;EINECS 250-374-6;1-[1-[2-[[6-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[1-[4-methyl-2-[[2-[(5-oxopyrrolidine-2-carbonyl)amino]acetyl]amino]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid;Bradykinin-Potentiator B;JXGBFZMUUPNIBD-UHFFFAOYSA-N;IAB-4009-V;DA-61858;Bradykinin potentiator B, >=97% (TLC);1-(1-{2-[6-AMINO-2-({1-[5-CARBAMIMIDAMIDO-2-({1-[1-(4-METHYL-2-{2-[(5-OXOPYRROLIDIN-2-YL)FORMAMIDO]ACETAMIDO}PENTANOYL)PYRROLIDINE-2-CARBONYL]PYRROLIDIN-2-YL}FORMAMIDO)PENTANOYL]PYRROLIDIN-2-YL}FORMAMIDO)HEXANAMIDO]-3-METHYLPENTANOYL}PYRROLIDINE-2-CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID;Pyr-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro, Bradykinin-Potentiator B Peptide (Mamushi, Agkistrodon halys blomhoffii);
Bradykinin potentiator B is a peptide compound originally isolated from the venom of Bothrops jararaca, recognized for its ability to enhance the physiological effects of bradykinin. As a biologically active oligopeptide, it modulates the kallikrein-kinin system by inhibiting the degradation of bradykinin, thus amplifying its vasodilatory and hypotensive actions in experimental settings. The unique mechanism of action and structural features of bradykinin potentiator B have made it a valuable tool in biochemical and pharmacological research, especially in studies exploring peptide-mediated signaling, enzyme inhibition, and vascular biology. Its role as a modulator of angiotensin-converting enzyme (ACE) activity further underscores its importance in the investigation of cardiovascular regulatory pathways and peptide-protein interactions.
Peptide signaling research: In the context of peptide signaling, bradykinin potentiator B serves as a reference molecule for elucidating the mechanisms underlying the amplification of bradykinin-mediated responses. Researchers utilize this peptide to dissect the signaling pathways involved in vascular permeability, smooth muscle contraction, and inflammatory processes. By modulating the breakdown of endogenous bradykinin, it enables precise investigation of downstream effector mechanisms and receptor interactions, providing insight into the physiological roles of kinins and their regulation.
Enzyme inhibition studies: The compound is frequently employed as a selective inhibitor of angiotensin-converting enzyme in biochemical assays. Its ability to inhibit ACE activity makes it a valuable probe for mapping the enzymatic cleavage of peptide substrates and for characterizing the specificity and kinetics of ACE-related processes. These studies contribute to a deeper understanding of peptide metabolism and the regulation of vasoactive peptides, supporting the development of novel enzyme inhibitors and therapeutic leads in a purely research context.
Vascular biology investigations: Bradykinin potentiator B is instrumental in experimental models designed to evaluate vascular reactivity and endothelial function. By enhancing bradykinin action, it allows researchers to assess the contribution of the kallikrein-kinin system to vasodilation, blood pressure regulation, and microvascular permeability. Such studies are critical for unraveling the complex interplay between peptides, enzymes, and receptors that govern vascular homeostasis and pathophysiological responses.
Peptide structure-activity relationship (SAR) analysis: The distinct sequence and bioactivity of bradykinin potentiator B make it a model compound for structure-activity relationship investigations within the field of peptide chemistry. By comparing its effects with those of related peptides and synthetic analogs, scientists can identify key structural determinants responsible for ACE inhibition and bradykinin potentiation. These SAR studies facilitate the rational design of new peptide-based modulators and expand the toolkit available for probing peptide-enzyme interactions.
Peptide synthesis and analytical method development: In addition to its functional applications, bradykinin potentiator B is used as a reference standard and substrate in the development and validation of peptide synthesis protocols and analytical techniques. Its well-characterized sequence and biological activity support method optimization in high-performance liquid chromatography (HPLC), mass spectrometry, and peptide purification workflows. These applications are essential for ensuring reproducibility and accuracy in peptide research, as well as for advancing the synthesis of bioactive peptide derivatives.
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