Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).
CAT No: R1261
Calcitonin Gene Related Peptide (CGRP) (83-119), rat, is a synthetic peptide fragment corresponding to amino acids 83 through 119 of the rat calcitonin gene-related peptide sequence. As a member of the neuropeptide family, CGRP plays a pivotal role in the modulation of vascular tone, nociception, and neurotransmission. The specific (83-119) fragment represents the biologically active region of the peptide, making it a valuable tool for exploring the physiological and pharmacological actions of CGRP in rodent models. Its high degree of sequence conservation with mammalian CGRP variants further enhances its relevance in comparative studies aimed at elucidating peptide structure-function relationships, receptor interactions, and downstream signaling mechanisms.
Receptor binding and signaling studies: CGRP (83-119) is frequently employed in receptor binding assays to characterize the affinity and selectivity of CGRP receptors in various tissues. Researchers use this peptide fragment to investigate the molecular determinants of receptor activation, enabling detailed analysis of ligand-receptor interactions within the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) complexes. Such studies are essential for mapping the pharmacological profile of the CGRP system and for identifying novel receptor modulators or antagonists for basic research purposes.
Vascular biology research: In vascular physiology, CGRP (83-119) serves as a potent vasodilatory agent, facilitating in vitro and ex vivo studies of arterial smooth muscle relaxation and endothelium-dependent responses. By applying this peptide to isolated vessel preparations or cultured endothelial cells, investigators can dissect the signaling pathways mediating CGRP-induced vasodilation, including the involvement of cyclic AMP, nitric oxide, and potassium channel modulation. These insights are critical for understanding the regulatory mechanisms underlying vascular homeostasis and neurogenic inflammation.
Neuroscience and pain pathway analysis: The peptide fragment is widely utilized in neuroscience research to probe the role of CGRP in sensory neurotransmission and pain modulation. Experimental models leveraging CGRP (83-119) allow for the assessment of its effects on neuronal excitability, synaptic transmission, and neuropeptide release in dorsal root ganglia and spinal cord preparations. Such studies contribute to a deeper understanding of the molecular basis of nociceptive signaling, migraine pathophysiology, and the broader neurobiology of pain.
Peptide structure-function studies: CGRP (83-119) is instrumental in elucidating the relationship between peptide structure and biological activity. Its defined amino acid sequence provides a platform for structure-activity relationship (SAR) analyses, including alanine scanning, truncation, or site-directed mutagenesis. By systematically modifying residues within this fragment, researchers can pinpoint critical determinants of receptor binding, agonist potency, and downstream signaling efficacy, thereby informing the rational design of peptide analogs or antagonists for experimental use.
Peptide synthesis and analytical validation: As a well-characterized neuropeptide fragment, CGRP (83-119) is also employed as a standard or reference material in the development and validation of peptide synthesis protocols and analytical methods. Its use in high-performance liquid chromatography (HPLC), mass spectrometry, and bioassay calibration supports the optimization of peptide production workflows and ensures the reliability of quantitative and qualitative assessments in peptide research laboratories.
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