Colivelin is a neuroprotective peptide and activator of STAT3.
CAT No: R1295
CAS No:867021-83-8
Synonyms/Alias:COLIVELIN;867021-83-8;Colivelin TFA;Colivelin?;Colivelin trifluoroacetate salt;s9664;AKOS024457889;FC109801;TS-10482;H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH; H-SALLRSIPAPAGASRLLLLT GEIDLP-OH;
Colivelin is a synthetic peptide compound designed by combining structural elements from activity-dependent neurotrophic factor (ADNF) and humanin, both of which are neuroprotective peptides. As a hybrid peptide, Colivelin exhibits unique biochemical properties that allow it to modulate cellular signaling pathways associated with neuronal survival and stress response. Its robust ability to engage multiple neuroprotective mechanisms has made it a valuable research tool in the study of cellular resilience, neurodegeneration, and peptide-based signaling. The multifunctional nature of Colivelin underpins its significance in advanced peptide research, particularly in elucidating the molecular underpinnings of neuronal maintenance and peptide-mediated cytoprotection.
Neuroprotection research: Colivelin is widely utilized in experimental models investigating mechanisms of neuroprotection. Its chimeric structure enables dual activation of the STAT3 and PI3K/Akt pathways, both of which are crucial for promoting neuronal survival under stress conditions. Researchers employ this peptide in cell-based assays and organotypic cultures to dissect how peptide signaling can mitigate apoptosis and oxidative damage, providing insights into the cellular processes that preserve neuronal integrity in the face of toxic insults.
Peptide signaling pathway studies: The hybrid nature of Colivelin makes it an ideal probe for dissecting complex peptide-mediated signaling cascades. By engaging both ADNF- and humanin-related receptors, it allows researchers to differentiate between overlapping and distinct downstream effects of these neurotrophic factors. Experimental use of the peptide in signaling assays helps clarify the cross-talk between JAK/STAT and PI3K/Akt pathways, supporting the development of new models for peptide-driven cellular communication and survival.
Oxidative stress modeling: Colivelin is frequently employed in studies aimed at understanding cellular responses to oxidative stress. Its capacity to activate endogenous protective pathways provides a platform for investigating how neurons and other cell types adapt to elevated reactive oxygen species. By incorporating this peptide into oxidative stress assays, scientists can evaluate the efficacy of endogenous defense mechanisms, study the interplay between peptide signaling and antioxidant responses, and identify molecular targets for enhancing cellular resilience.
Peptide structure-activity relationship (SAR) analysis: As a rationally designed hybrid peptide, Colivelin serves as a model system for structure-activity relationship investigations. Researchers utilize it to map the functional domains responsible for receptor binding, signal transduction, and cytoprotective effects. SAR studies involving Colivelin contribute to the broader understanding of how sequence modifications in neurotrophic peptides influence their biological activity, guiding the design of next-generation peptide analogs with optimized properties.
In vitro assay development: The unique biochemical profile of Colivelin supports its use in the development and validation of in vitro assays targeting peptide-mediated neuroprotection and cell survival. Its well-characterized activity enables the establishment of reproducible positive controls in high-throughput screening platforms, facilitating the identification of small molecules or peptide analogs with similar or enhanced efficacy. The peptide's application in assay development enhances the reliability and interpretability of experimental data in neurobiology and peptide pharmacology research.
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