Compstatin

Name: Compstatin
Brand: Creative Peptides
SKU: R0889
Availability: MadeToOrder

Compstatin is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. It acts as a potent inhibitor of the complement system.

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CAT No: R0889

CAS No: 206645-99-0

Synonyms/Alias: COMPSTATIN;206645-99-0;CHEMBL266963;CID 16220219;Compstatin?;ICVVQDWGHHRCT-NH2;Compstatin trifluoroacetate salt;GTPL9218;BDBM50241352;AKOS024457182;CCG-270690;AC-33698;FC109863;D80482;Q27076880;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2; H-ICVVQDWGHHRCT-NH2;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C66H99N23O17S2
M.W/Mr.	1550.8
Sequence	One Letter Code:ICVVQDWGHHRCT Three Letter Code:H-Ile-Cys(1)-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys(1)-Thr-NH2
Biological Activity	Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Long-term Storage Conditions	Soluble to 2 mg/ml in water
Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C66H99N23O17S2/c1-8-32(6)50(68)63(104)86-46-27-108-107-26-45(62(103)89-53(33(7)90)54(69)95)85-56(97)39(14-11-17-74-66(70)71)80-59(100)43(20-36-24-73-29-78-36)83-58(99)42(19-35-23-72-28-77-35)79-48(92)25-76-55(96)41(18-34-22-75-38-13-10-9-12-37(34)38)82-60(101)44(21-49(93)94)84-57(98)40(15-16-47(67)91)81-64(105)51(30(2)3)88-65(106)52(31(4)5)87-61(46)102/h9-10,12-13,22-24,28-33,39-46,50-53,75,90H,8,11,14-21,25-27,68H2,1-7H3,(H2,67,91)(H2,69,95)(H,72,77)(H,73,78)(H,76,96)(H,79,92)(H,80,100)(H,81,105)(H,82,101)(H,83,99)(H,84,98)(H,85,97)(H,86,104)(H,87,102)(H,88,106)(H,89,103)(H,93,94)(H4,70,71,74)/t32-,33+,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-,53-/m0/s1
InChI Key	RDTRHBCZFDCUPW-KWICJJCGSA-N

1. P-selectin and Complement’s Role in a Neonatal Model of Germinal Matrix Hemorrhage-Induced Secondary Injury

2. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

3. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

4. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

5. C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients

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