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Compstatin

Compstatin is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. It acts as a potent inhibitor of the complement system.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Compstatin(CAS 206645-99-0)

CAT No: R0889

CAS No:206645-99-0

Synonyms/Alias:COMPSTATIN;206645-99-0;CHEMBL266963;CID 16220219;Compstatin?;ICVVQDWGHHRCT-NH2;Compstatin trifluoroacetate salt;GTPL9218;BDBM50241352;AKOS024457182;CCG-270690;AC-33698;FC109863;D80482;Q27076880;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2; H-ICVVQDWGHHRCT-NH2;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C66H99N23O17S2
M.W/Mr.
1550.8
Sequence
One Letter Code:ICVVQDWGHHRCT
Three Letter Code:H-Ile-Cys(1)-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys(1)-Thr-NH2
Biological Activity
Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.
Long-term Storage Conditions
Soluble to 2 mg/ml in water
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C66H99N23O17S2/c1-8-32(6)50(68)63(104)86-46-27-108-107-26-45(62(103)89-53(33(7)90)54(69)95)85-56(97)39(14-11-17-74-66(70)71)80-59(100)43(20-36-24-73-29-78-36)83-58(99)42(19-35-23-72-28-77-35)79-48(92)25-76-55(96)41(18-34-22-75-38-13-10-9-12-37(34)38)82-60(101)44(21-49(93)94)84-57(98)40(15-16-47(67)91)81-64(105)51(30(2)3)88-65(106)52(31(4)5)87-61(46)102/h9-10,12-13,22-24,28-33,39-46,50-53,75,90H,8,11,14-21,25-27,68H2,1-7H3,(H2,67,91)(H2,69,95)(H,72,77)(H,73,78)(H,76,96)(H,79,92)(H,80,100)(H,81,105)(H,82,101)(H,83,99)(H,84,98)(H,85,97)(H,86,104)(H,87,102)(H,88,106)(H,89,103)(H,93,94)(H4,70,71,74)/t32-,33+,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-,53-/m0/s1
InChI Key
RDTRHBCZFDCUPW-KWICJJCGSA-N

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