Compstatin

Compstatin is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. It acts as a potent inhibitor of the complement system.

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CAT No: R0889

CAS No: 206645-99-0

Synonyms/Alias: COMPSTATIN;206645-99-0;CHEMBL266963;CID 16220219;Compstatin?;ICVVQDWGHHRCT-NH2;Compstatin trifluoroacetate salt;GTPL9218;BDBM50241352;AKOS024457182;CCG-270690;AC-33698;FC109863;D80482;Q27076880;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2; H-ICVVQDWGHHRCT-NH2;

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M.F/FormulaC66H99N23O17S2
M.W/Mr.1550.8
SequenceOne Letter Code:ICVVQDWGHHRCT
Three Letter Code:H-Ile-Cys(1)-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys(1)-Thr-NH2
Biological ActivityComplement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.
Long-term Storage ConditionsSoluble to 2 mg/ml in water
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C66H99N23O17S2/c1-8-32(6)50(68)63(104)86-46-27-108-107-26-45(62(103)89-53(33(7)90)54(69)95)85-56(97)39(14-11-17-74-66(70)71)80-59(100)43(20-36-24-73-29-78-36)83-58(99)42(19-35-23-72-28-77-35)79-48(92)25-76-55(96)41(18-34-22-75-38-13-10-9-12-37(34)38)82-60(101)44(21-49(93)94)84-57(98)40(15-16-47(67)91)81-64(105)51(30(2)3)88-65(106)52(31(4)5)87-61(46)102/h9-10,12-13,22-24,28-33,39-46,50-53,75,90H,8,11,14-21,25-27,68H2,1-7H3,(H2,67,91)(H2,69,95)(H,72,77)(H,73,78)(H,76,96)(H,79,92)(H,80,100)(H,81,105)(H,82,101)(H,83,99)(H,84,98)(H,85,97)(H,86,104)(H,87,102)(H,88,106)(H,89,103)(H,93,94)(H4,70,71,74)/t32-,33+,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-,53-/m0/s1
InChI KeyRDTRHBCZFDCUPW-KWICJJCGSA-N
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