CTCE 9908 acts as a CXCR4 antagonist that induces mitotic catastrophe in ovarian cancer cells. When given with taxol, it displays additive cytotoxic effects.
CAT No: R0977
CAS No:1030384-98-5
Synonyms/Alias:CTCE 9908;1030384-98-5;CTCE-9908;UNII-NF0BX95A31;L-Lysinamide, N2,N6-bis(L-lysylglycyl-L-valyl-L-seryl-L-leucyl-L-seryl-L-tyrosyl-L-arginyl)-;NF0BX95A31;PTX-9908 FREE BASE;CTCE 9908 TFA;CTCE9908;SDF-1 Analog PTX-9908;CHEMBL3544949;SDF-1 (108) Lysine Dlmer;CXCR4 Antagonist CTCE-9908;PTX9908;PTX 9908;PTX-9908;SDF-1 Receptor Antagonist PTX-9908;DA-52152;G14352;Q27284835;L-Lysinamide,N2,N6-bis(L-lysylglycyl-L-valyl-L-seryl-L-leucyl-L-seryl-L-tyrosyl-L-arginyl)-;
CTCE 9908 is a synthetic peptide compound designed as a chemokine receptor antagonist, specifically targeting the CXCR4 receptor. As a structurally engineered peptide, it plays a significant role in the study of chemokine-mediated signaling pathways, cell migration, and related physiological processes. Its sequence and conformational properties enable selective interaction with CXCR4, making it a valuable research tool for dissecting the molecular mechanisms underlying chemokine receptor function. CTCE 9908 has gained prominence in biochemical and cellular research due to its ability to modulate receptor-ligand interactions, providing insights into diverse biological phenomena such as immune cell trafficking, tumor cell behavior, and tissue remodeling.
Receptor Binding Studies: In the context of receptor-ligand binding assays, CTCE 9908 serves as a potent tool for investigating the affinity, specificity, and kinetics of CXCR4 interactions. By competitively inhibiting the binding of natural chemokines such as CXCL12 (SDF-1α) to CXCR4, it enables researchers to delineate the structural determinants of receptor recognition and activation. These studies are vital for mapping the functional domains of chemokine receptors and for identifying key amino acid residues involved in ligand engagement, which can inform the rational design of novel antagonists or modulators.
Cell Migration Assays: The peptide is widely utilized in cell migration and chemotaxis assays to elucidate the role of CXCR4 signaling in cellular motility. By blocking the CXCL12/CXCR4 axis, CTCE 9908 allows for precise analysis of how chemokine gradients influence the directional movement of various cell types, including immune cells, progenitor cells, and cancer cells. These assays are fundamental for understanding mechanisms of tissue homing, inflammatory responses, and metastatic dissemination, providing a controlled system for evaluating the impact of receptor inhibition on cell behavior.
Signal Transduction Research: CTCE 9908 is instrumental in dissecting downstream signaling pathways activated by CXCR4 engagement. Its antagonistic action facilitates the study of intracellular cascades such as calcium mobilization, MAPK activation, and PI3K/Akt signaling following chemokine stimulation. By modulating receptor activity, the peptide enables researchers to investigate the molecular consequences of CXCR4 blockade, offering insights into the regulation of gene expression, cytoskeletal dynamics, and cellular survival mechanisms.
Peptide Structure-Activity Relationship (SAR) Analysis: As a synthetic peptide, CTCE 9908 is valuable for structure-activity relationship studies aimed at optimizing chemokine receptor antagonists. Researchers employ it as a reference compound to assess the impact of sequence modifications, backbone alterations, or chemical modifications on biological activity and receptor binding. Such SAR investigations are essential for advancing peptide-based drug design and for developing next-generation molecules with improved pharmacological profiles.
In vivo and Ex vivo Modeling: The compound is also applied in in vivo and ex vivo experimental systems to model the physiological and pathological roles of CXCR4 signaling. By administering CTCE 9908 in animal models or organotypic cultures, researchers can evaluate the effects of targeted chemokine receptor inhibition on processes such as immune cell trafficking, tissue repair, and disease progression. These studies contribute to a deeper understanding of chemokine biology and support the development of targeted interventions in translational research settings.
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