Cyclo(D-Ser-Pro-D-Val-Leu-D-Trp) contains alternating D-amino acids that impose a rigid macrocyclic topology. Its hydrophobic and polar residues create defined interaction surfaces. The cyclic structure supports studies of conformational constraints and receptor recognition. Applications include biophysical modeling, ligand design, and peptide engineering.
1. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
2. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
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