Cyclotraxin B

Cyclotraxin B is highly potent and selective TrkB receptor antagonist that inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). It allosterically changes the conformation of TrkB receptor, but does not change BDNF binding.

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CAT#R0881
CAS1203586-72-4
M.F/FormulaC48H73N13O17S3
M.W/Mr.1200.36
SequenceCNPMGYTKEGC(Disulfide bridge between Cys1-Cys11)
Labeling TargetTrkB receptor
AppearanceWhite lyophilised solid
Purity>98 %
ActivityAntagonist
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