Cyclotraxin B is highly potent and selective TrkB receptor antagonist that inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). It allosterically changes the conformation of TrkB receptor, but does not change BDNF binding.
CAT# | R0881 |
CAS | 1203586-72-4 |
M.F/Formula | C48H73N13O17S3 |
M.W/Mr. | 1200.36 |
Sequence | CNPMGYTKEGC(Disulfide bridge between Cys1-Cys11) |
Labeling Target | TrkB receptor |
Appearance | White lyophilised solid |
Purity | >98 % |
Activity | Antagonist |
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