(D-Ala2,N-Me-Phe4,glycinol5)-Enkephalin is a modified enkephalin analog featuring a D-alanine substitution at position 2 and a N-methylphenylalanine at position 4. These changes enhance stability and reduce susceptibility to enzymatic degradation, while the glycinol modification at position 5 alters receptor binding dynamics. Researchers use it to study opioid receptor subtypes and to probe the structure-activity relationship of enkephalin-like peptides.
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
2. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
4. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
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