3,5-Diiodo-D-tyrosine is a halogenated, non-proteinogenic derivative of the amino acid tyrosine in which two iodine atoms are substituted at the 3- and 5-positions of the phenolic ring while the molecule retains the amino acid backbone with an amino group and a carboxyl group. The side chain bears a phenolic hydroxyl that remains available for chemical derivatization or hydrogen-bonding interactions, and the stereochemistry is specified as D for the α-carbon configuration. This iodinated amino acid is used in chemical biology and analytical research as a stable, radioiodine-compatible structural analog for studying iodinated aromatic residues, supporting labeling and conjugation strategies, and providing a defined building block for the preparation of more complex iodinated amino acid and peptide derivatives.
CAT No: CP18202
3,5-Diiodo-D-tyrosine is a halogenated tyrosine analog featuring two iodine atoms on the aromatic ring and a D-configuration at the amino acid stereocenter. This dense iodination pattern makes it a widely used building block for radiolabeling and iodine-containing biochemical probes, while the D-amino acid configuration supports applications where resistance to proteolysis or altered biological handling is advantageous in experimental designs. In chemical biology and analytical workflows, its defined iodination level provides a consistent platform for preparing iodine-specific standards and tagged derivatives.
1. Radiolabeling And Tracing
3,5-Diiodo-D-tyrosine is used as a precursor for generating iodine-containing labeled tyrosine derivatives for tracer studies in chemical biology and radiochemistry workflows. Researchers rely on the fixed 3,5-diiodo substitution to produce reproducible iodinated targets that can be incorporated into probe molecules or used to calibrate labeling steps. The D-configuration is commonly selected in experimental designs that aim to reduce enzymatic turnover during incubation-based assays, supporting more stable tracer behavior in time-resolved experiments.
2. Iodinated Probe And Conjugate Synthesis
3,5-Diiodo-D-tyrosine serves as an iodinated aromatic amino acid building block for constructing chemical biology probes and conjugates where an iodine-rich tyrosine motif is required. Teams developing affinity reagents, enzyme substrate analogs, or detection-tagged ligands often choose this scaffold because the diiodophenyl ring provides a robust handle for downstream functionalization while maintaining a defined aromatic substitution pattern. The amino acid functionality also supports straightforward incorporation into peptide-like constructs and other structured ligands used in binding and interaction studies.
3. Analytical Standards For Iodinated Species
3,5-Diiodo-D-tyrosine is frequently used to prepare analytical reference materials for quantifying iodinated tyrosine species in method development and routine quality control of analytical assays. Laboratories developing LC-MS or related workflows benefit from having a structurally defined iodinated standard that matches the key substitution motif on the aromatic ring. This helps improve identification confidence and supports calibration strategies when monitoring iodine-containing metabolites, derivatized tyrosine analogs, or assay components that include diiodophenyl structures.
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
4. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
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