Golotimod

Golotimod is an orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Golotimod(CAS 229305-39-9)

CAT No: 10-101-250

CAS No:229305-39-9

Synonyms/Alias:Golotimod;229305-39-9;SCV-07;Golotimod [USAN];gamma-D-Glu-L-trp;SCV07;gamma-D-Glutamyl-L-tryptophan;SCV 07;Golotimod [USAN:INN];H-D-Glu(Trp-OH)-OH;GOLOTIMOD [INN];GOLOTIMOD [WHO-DD];(2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid;637C487Y09;L-Tryptophan, D-gamma-glutamyl-;DTXSID10177474;D-.GAMMA.-GLUTAMYL-L-TRYPTOPHAN;(R)-2-Amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid;(2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid;golotimodum;(2R)-2-amino-4-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)carbamoyl)butanoic acid;(2R)-2-AMINO-4-{[(1S)-1-CARBOXY-2-(1H-INDOL-3-YL)ETHYL]CARBAMOYL}BUTANOIC ACID;UNII-637C487Y09;MFCD28137704;Golotimod (SCV-07);Golotimod (USAN/INN);Golotimod (SCV-07)?;H-D-Glu(L-Trp-OH)-OH;(gamma-glutamyl-L-tryptophan);SCHEMBL727944;CHEMBL2103812;DTXCID3099965;CATMPQFFVNKDEY-YPMHNXCESA-N;CHEBI:177459;BCP24651;D-GAMMA-GLUTAMYL-L-TRYPTOPHAN;EX-A10956;NSC755401;AKOS030573318;DB05475;NSC-755401;FG108327;HY-14743;MS-25023;DB-230492;CS-0003532;NS00068645;D08928;G14394;Q27095684;H-D-Glu(L-Trp-OH)-OH;SCV 07;gamma-D-Glu-L-trp;SCV-07;SCV07;(2R)-2-amino-5-[[(1S)-2-hydroxy-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid;

Chemical Name:(R)-2-amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C16H19N3O5
M.W/Mr.
333.34
Sequence
One Letter Code:XW
Three Letter Code:H-D-gGlu-Trp-OH
Appearance
White solid powder
Purity
>98%

Golotimod, also known as SCV-07, is a synthetic dipeptide derived from naturally occurring amino acids, recognized for its immunomodulatory properties and its ability to influence various cellular pathways. As a carbohydrate compound, Golotimod has garnered significant interest within the scientific community due to its unique molecular structure and its potential to modulate immune responses. Its stability and solubility make it an attractive candidate for research settings, facilitating its integration into a wide array of experimental protocols. Researchers value Golotimod for its versatility, as it can be incorporated into both in vitro and in vivo studies, offering a robust tool for investigating immune mechanisms and cellular signaling processes.

Immunology research: In immunology research, Golotimod serves as a valuable agent for studying the modulation of immune cell activity. By influencing cytokine production and enhancing the function of T lymphocytes, it provides researchers with a means to dissect complex immune pathways. Its application allows for the exploration of how immune responses can be upregulated or downregulated, aiding scientists in understanding the delicate balance required for effective immunity without triggering autoimmunity or excessive inflammation.

Cell signaling studies: The use of SCV-07 in cell signaling studies enables detailed analysis of intracellular communication and pathway activation. Its interaction with specific receptors and subsequent effects on signal transduction cascades make it a powerful tool for mapping out the molecular events that govern cell behavior. Researchers employ this compound to unravel the intricacies of how external stimuli are translated into cellular responses, which is critical for identifying potential targets for therapeutic intervention.

Drug development research: In the realm of drug development, Golotimod is often utilized as a lead compound or as a molecular scaffold for the design of new immunomodulatory agents. Its well-characterized structure and known bioactivity profile provide a solid foundation for structure-activity relationship (SAR) studies. Scientists leverage its properties to synthesize analogs with improved efficacy or selectivity, thereby accelerating the discovery pipeline for novel agents that can modulate immune function for research purposes.

Vaccine adjuvant investigation: As a potential vaccine adjuvant, SCV-07 is studied for its capacity to enhance antigen-specific immune responses. By promoting the activation and proliferation of immune cells in response to antigens, it supports the development of more robust and durable immunity in experimental models. This application is particularly relevant for researchers aiming to optimize vaccine formulations and understand the factors that contribute to effective immunization strategies.

Inflammation mechanism exploration: Golotimod is also employed in studies focused on the mechanisms underlying inflammation. Its ability to modulate the production of pro-inflammatory and anti-inflammatory mediators allows scientists to investigate the triggers and regulators of inflammatory processes. Through these investigations, researchers gain insights into the molecular events that drive inflammation and identify potential molecular targets for modulating inflammatory responses in various disease models.

Biochemical pathway elucidation: In addition to its established roles, SCV-07 is increasingly utilized in efforts to elucidate broader biochemical pathways involved in immune regulation and cellular homeostasis. By serving as a probe in complex experimental systems, it aids in mapping out the interactions between signaling molecules, enzymes, and cellular receptors. These studies contribute to a more comprehensive understanding of the networks that maintain immune balance and cellular integrity, supporting the advancement of basic and translational research in immunology and related fields.

Long-term Storage Conditions
Soluble in DMSO, not in water
InChI
InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13+/m1/s1
InChI Key
CATMPQFFVNKDEY-YPMHNXCESA-N
Canonical SMILES
O=C(O)[C@H](N)CCC(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)=O

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