Melanocyte protein PMEL;gp100
CAT No: ta-023
CAS No:181477-43-0
Synonyms/Alias:Disomotide;181477-43-0;Disomotide [USAN:INN];UNII-8028PPX4PM;disomotida;MPS 22;MPS-22;8028PPX4PM;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoic acid;DTXSID50171158;Gp100:209-217(210m) peptide;Gp-100:209-217(210m) peptide;(186-L-Methionine)melanocyte protein Pmel 17 (human melanoma-associated ME20 antigen)-(185-193)-peptide;L-Valine, L-isoleucyl-L-methionyl-L-alpha-aspartyl-L-glutaminyl-L-valyl-L-prolyl-L- phenylalanyl-L-seryl-;Disomotide [USAN];disomotidum;DISOMOTIDE [INN];DISOMOTIDE [WHO-DD];CHEMBL263429;DTXCID4093649;BDBM50409410;FM109412;HY-105039;Q27269103;H-Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val-OH; H-IMDQVPFSV-OH;(Met186)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) trifluoroacetate salt;L-VALINE, L-ISOLEUCYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-L-GLUTAMINYL-L-VALYL-L-PROLYL-L-PHENYLALANYL-L-SERYL-;L-VALINE, L-ISOLEUCYL-L-METHIONYL-L-ALPHA-ASPARTYL-L-GLUTAMINYL-L-VALYL-L-PROLYL-L-PHENYLALANYL-L-SERYL-;
gp100 (209-217) is a synthetic peptide corresponding to amino acid residues 209 to 217 of the human glycoprotein 100 (gp100), a melanoma-associated antigen widely studied in immunology and cancer research. As a defined epitope within the gp100 protein, this peptide is recognized by cytotoxic T lymphocytes (CTLs) and serves as a critical tool for investigating antigen processing, T cell recognition, and immune targeting of melanocytic cells. Its precise sequence and immunogenic properties have established it as a valuable reagent in the fields of tumor immunology, peptide-based assay development, and cellular immunotherapy research.
Epitope Mapping: In immunological research, gp100 (209-217) is extensively utilized for the mapping and characterization of T cell epitopes. By presenting this peptide to T cell populations, researchers can assess the specificity and functional responsiveness of cytotoxic T lymphocytes against gp100-expressing cells. Such studies are essential for elucidating the molecular determinants of antigen recognition and for identifying immunodominant regions relevant to tumor-associated antigens.
Antigen Presentation Studies: The peptide serves as a model substrate for investigating the mechanisms of antigen processing and presentation by major histocompatibility complex (MHC) class I molecules. By loading the peptide onto antigen-presenting cells, scientists can dissect the efficiency of peptide-MHC complex formation, peptide stability, and subsequent T cell activation. These applications are fundamental for understanding how immune surveillance operates at the molecular level and for optimizing antigen delivery strategies in experimental systems.
T Cell Activation Assays: gp100 (209-217) is frequently employed in functional assays to stimulate and monitor gp100-specific T cell responses. In vitro stimulation with this peptide enables quantification of cytokine production, proliferation, and cytolytic activity of antigen-specific T cells. Such assays are instrumental in evaluating the efficacy of immune interventions, screening for T cell reactivity, and validating peptide immunogenicity in preclinical research.
Peptide-Based Vaccine Research: The defined immunogenic sequence of this peptide makes it a candidate for use in the development and optimization of peptide-based vaccine platforms. Researchers leverage its ability to elicit targeted T cell responses in experimental models, facilitating the design and refinement of synthetic vaccines aimed at inducing robust cellular immunity against melanoma-associated antigens. These investigations support the broader goal of advancing antigen-specific immunotherapeutic strategies.
Assay Development and Standardization: As a well-characterized synthetic peptide, gp100 (209-217) is commonly incorporated into protocols for assay calibration, quality control, and standardization in immunological studies. Its use ensures reproducibility and comparability across experimental runs, particularly in flow cytometry, ELISPOT, and tetramer-based assays that quantify antigen-specific T cell populations. By providing a consistent and defined antigenic stimulus, it supports rigorous experimental design and data interpretation in both basic and translational research settings.
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