Humanin

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#R1848
ExplanationHumanin is an endogenous peptide that exhibits anti-apoptotic and neuroprotective activities. Humanin is overexpressed in some cancers and could possibly be used as a biomarker.
Synonyms/AliasHumanin, human; Protein Humanin (human)
M.F/FormulaC121H205F3N34O34S2
M.W/Mr.2801.26
SequenceOne Letter Code: MAPRGFSCLLLLTSEIDLPVKRRA
Three Letter Code: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
ApplicationNeuroprotective peptide
AppearanceWhite to off white powder
Purity≥95%
Activityhumanin activates formyl peptide receptor-like receptors 1 and 2 (FPRL1/2), inhibiting Bax-dependent apoptosis and suppressing JNK-mediated cell death. Humanin also inhibits amyloid-β (Aβ)-induced neuronal death in vitro and its effects in animal models of Alzheimer’s disease.
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