Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
|Explanation||Humanin is an endogenous peptide that exhibits anti-apoptotic and neuroprotective activities. Humanin is overexpressed in some cancers and could possibly be used as a biomarker.|
|Synonyms/Alias||Humanin, human; Protein Humanin (human)|
|Sequence||One Letter Code: MAPRGFSCLLLLTSEIDLPVKRRA|
Three Letter Code: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
|Appearance||White to off white powder|
|Activity||humanin activates formyl peptide receptor-like receptors 1 and 2 (FPRL1/2), inhibiting Bax-dependent apoptosis and suppressing JNK-mediated cell death. Humanin also inhibits amyloid-β (Aβ)-induced neuronal death in vitro and its effects in animal models of Alzheimer’s disease.|
|Long-term Storage Conditions||Soluble in formic acid (1 mg/mL), 5% acetic acid.||Shipping Condition||Ambient|
|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|R1544||Neuropeptide Y (13-36), amide, human||Inquiry|
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