Interleukin (IL)-6 Receptor is a peptide, derived from interleukin-6 receptor.
CAT No: R1455
Interleukin (IL)-6 Receptor is a critical membrane-bound and soluble protein complex involved in mediating the biological activities of the cytokine interleukin-6 (IL-6). Functioning as a key component of the IL-6 signaling pathway, the receptor plays a pivotal role in immune regulation, inflammation, hematopoiesis, and various cellular responses. Its biochemical significance extends to the modulation of signal transduction processes that influence gene expression, cell proliferation, differentiation, and survival. The IL-6 receptor, comprising both the IL-6Rα subunit and the signal-transducing gp130 component, is widely studied for its involvement in physiological and pathological processes, making it an indispensable tool in immunology, cell biology, and molecular research.
Signal Transduction Studies: The IL-6 receptor is extensively utilized in investigations aimed at elucidating the mechanisms of cytokine-mediated signaling. Researchers employ the receptor in cell-based assays and molecular studies to dissect the downstream activation of pathways such as JAK/STAT, MAPK, and PI3K/Akt. By enabling controlled activation or inhibition of these signaling cascades, the receptor facilitates detailed analysis of gene regulation, receptor-ligand interactions, and cellular responses to inflammatory stimuli. This is particularly valuable for mapping the molecular events that underpin immune cell differentiation and function.
Immunology Research: The receptor is a fundamental reagent in immunological studies exploring the modulation of immune cell populations, including T cells, B cells, and macrophages. Its role in driving the differentiation of T helper 17 (Th17) cells and influencing acute-phase responses is of particular interest. Experimental systems incorporating the IL-6 receptor allow for the investigation of cytokine cross-talk, immune cell activation, and the orchestration of inflammatory networks. Such studies provide critical insights into the regulation of immune homeostasis and the development of immune-mediated conditions.
Inflammation and Disease Modeling: The IL-6 receptor is widely applied in the development of in vitro and in vivo models of inflammation and immune dysregulation. By manipulating receptor expression or function, scientists can simulate disease-relevant conditions such as chronic inflammation, autoimmunity, and cytokine storm syndromes. These models are instrumental for unraveling the cellular and molecular drivers of disease progression, identifying biomarkers, and evaluating the impact of novel compounds on inflammatory pathways.
Biomarker Discovery and Validation: Utilizing the IL-6 receptor in analytical assays supports the identification and validation of biomarkers associated with immune activation and inflammatory responses. Quantitative and qualitative analyses of receptor expression, distribution, and activity in various biological samples aid in correlating molecular signatures with disease states or experimental interventions. The receptor serves as a reference point for profiling cytokine networks and assessing the efficacy of immunomodulatory strategies in preclinical research.
Protein Engineering and Drug Discovery: The IL-6 receptor is an essential target in the design and screening of biologics, small molecules, and receptor antagonists. Recombinant forms of the receptor are employed in binding assays, structural biology studies, and high-throughput screening platforms to characterize ligand interactions and optimize candidate molecules. These applications are central to advancing the understanding of receptor function, improving assay specificity, and supporting the development of next-generation immunomodulatory agents for research purposes.
4. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
5. Cationic cell-penetrating peptides are potent furin inhibitors
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More