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This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4, derived from the IRAK-1 activation loop peptide amino acids 360 to 380. This peptide sequence contains Ser-376, one of the primary phospho-acceptor residues of IRAK-1. IRAK-4 phosphorylates IRAK-1 as a key step in regulation of inflammatory signaling pathways.
Peptide Library Construction and Screening
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M.W/Mr. | 2285.7 |
Sequence | One Letter Code: KKARFSRFAGSSPSQSSMVAR Three Letter Code: H-Lys-Lys-Ala-Arg-Phe-Ser-Arg-Phe-Ala-Gly-Ser-Ser-Pro-Ser-Gln-Ser-Ser-Met-Val-Ala-Arg-OH |
References | Hekmat-Nejad, M. et al. Biochem 49, 1495 (2010). |
1. Cationic cell-penetrating peptides are potent furin inhibitors
2. High fat diet and GLP-1 drugs induce pancreatic injury in mice
3. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
4. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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