Selective galanin GAL2 receptor antagonist that blocks the pro-nociceptive effect of GAL2 receptor agonists.
CAT No: R0871
CAS No:908844-75-7
Synonyms/Alias:908844-75-7;Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide;AKOS024457246;PD079345;galanin(2-13)Glu-His-(Pro)3(Ala-Leu)2Ala-amide;
M871 is a synthetic peptide compound designed for advanced biochemical and molecular biology research. As a sequence-defined peptide, it offers precise control over amino acid composition, enabling detailed investigation of protein-protein interactions, receptor binding, signal transduction pathways, and enzymatic mechanisms. Its well-characterized structure makes it a valuable tool in elucidating the functional roles of specific peptide motifs within biological systems. Researchers utilize such peptides to model natural protein fragments, develop assay systems, and explore structure-activity relationships essential to understanding cellular processes and molecular recognition events.
Peptide-Protein Interaction Studies: M871 is frequently applied in studies aimed at dissecting the molecular determinants of protein-protein interactions. By serving as a defined ligand or competitor in binding assays, it enables researchers to map interaction sites, quantify binding affinities, and identify critical residues involved in complex formation. Such investigations are fundamental in unraveling the mechanistic basis of signal transduction, scaffolding, or regulatory processes mediated by specific peptide domains.
Receptor Binding Assays: As a synthetic peptide with a known sequence, M871 is utilized in receptor binding assays to probe ligand-receptor specificity and affinity. Its application facilitates the identification of peptide recognition motifs and the characterization of receptor activation or inhibition mechanisms. These studies are essential for validating molecular targets, screening for modulators, and advancing the understanding of cellular communication networks.
Enzyme Substrate and Inhibitor Characterization: In enzymology research, M871 serves as a model substrate or competitive inhibitor to investigate protease specificity, catalytic efficiency, or regulatory control. By monitoring the enzymatic processing of this peptide, researchers can delineate substrate preferences, kinetic parameters, and potential inhibition profiles. Such data are crucial for elucidating enzyme function and informing the design of selective modulators or probes.
Structural Biology and Conformational Analysis: The defined nature of M871 makes it suitable for structural biology applications, including NMR spectroscopy, circular dichroism, or X-ray crystallography. It supports detailed analysis of peptide secondary structure, folding dynamics, and conformational stability under various conditions. Insights gained from these studies contribute to the broader understanding of peptide architecture and its influence on biological activity.
Peptide-Based Assay Development: M871 is often incorporated into custom assay platforms, such as fluorescence polarization, FRET, or ELISA-based systems, to enable quantitative detection of molecular interactions or enzymatic events. Its sequence specificity allows for the tailored design of assays that are both sensitive and selective for target analytes or activities. These platforms are widely adopted in basic research, drug discovery, and high-throughput screening environments, where reliable and reproducible detection reagents are essential.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
3. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More