This is a short cell-penetrating peptide (CPP) derived from the venom peptide of Tunician scorpion. It can permeate cell membrane at low micromolar concentration in minutes without significantly affecting cell membrane. Maurocalcine can be conjugated with large molecules and used as a drug delivery vehicle.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 1098.3 |
Sequence | H-Gly-Asp-Cys(acm)-Leu-Pro-His-Leu-Lys-Leu-Cys-OH |
1. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
3. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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