Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
CAT No: 10-101-319
CAS No:205640-91-1
Synonyms/Alias:Orexin B (human);205640-91-1;Orexin B, human TFA;Human orexin B TFA;(Met-28 = C-terminal amide);RSGPPGLQGRLQRLLQASGNHAAGILTM;C123H212N44O35S;HB5323;AKOS024456609;Orexin B (human) trifluoroacetate salt;FO109202;PD079176;H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala -Gly-Ile-Leu-Thr-Met-NH2; H-RSGPPGLQGR LQRLLQASGNHAAGILTM-NH2;
Orexin B human is a synthetic peptide that corresponds to the endogenous neuropeptide Orexin B, also known as hypocretin-2, which is naturally produced in the hypothalamus. As a member of the orexin peptide family, it plays a pivotal role in regulating arousal, wakefulness, appetite, and energy homeostasis through its interaction with orexin receptors OX1R and OX2R. The unique sequence and structure of Orexin B human make it a valuable tool for scientific studies aimed at elucidating neuropeptide signaling pathways, receptor pharmacology, and the broader physiological functions of the orexin system. Its use in research has contributed significantly to the understanding of neural mechanisms underlying sleep-wake cycles, feeding behavior, and neuroendocrine regulation.
Receptor binding studies: Orexin B human is widely utilized in receptor binding assays to characterize the specificity, affinity, and activation mechanisms of orexin receptors, particularly OX2R. By employing radiolabeled or fluorescently tagged versions of the peptide, researchers can quantitatively assess ligand-receptor interactions, enabling the mapping of binding sites and the evaluation of receptor pharmacodynamics. Such studies are essential for the development of selective agonists or antagonists targeting the orexinergic system, with implications for neurobiology and pharmacological research.
Neuropeptide signaling research: The peptide serves as a critical tool in dissecting the signaling cascades initiated by orexin receptor activation. By applying Orexin B human to cultured neurons or brain slice preparations, investigators can monitor downstream effects such as changes in intracellular calcium, cAMP levels, or phosphorylation states of key signaling proteins. These experiments provide mechanistic insights into how orexin peptides modulate neuronal excitability, synaptic plasticity, and network oscillations within the central nervous system.
Behavioral neuroscience: In vivo administration of Orexin B human in animal models enables the investigation of its role in modulating physiological and behavioral processes such as sleep architecture, feeding motivation, and stress responses. Through stereotaxic microinjection or intracerebroventricular delivery, its effects on locomotor activity, sleep-wake transitions, and food intake can be systematically evaluated. These studies are fundamental for unraveling the neurobiological substrates of arousal and energy balance.
Peptide structure-activity relationship (SAR) studies: The defined amino acid sequence of Orexin B human makes it an ideal reference compound for SAR analyses. By comparing the biological activity of native Orexin B to that of analogs with single or multiple residue substitutions, researchers can determine critical sequence motifs responsible for receptor selectivity and efficacy. Such investigations inform the rational design of novel peptide ligands with tailored pharmacological profiles for experimental or preclinical applications.
Drug discovery and screening: Orexin B human is frequently incorporated into high-throughput screening platforms for the identification of small molecules or biologics that modulate orexin receptor function. The peptide's well-characterized activity profile allows it to serve as a positive control or standard in functional assays, facilitating the discovery of new modulators that may influence sleep, appetite, or neuropsychiatric pathways. This application supports both academic research and early-stage pharmaceutical development targeting neuropeptide signaling systems.
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