PDGFR740Y-P

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.

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CAT#R0897
Chemical Structure
CAS1236188-16-1
Synonyms/Alias40YPDGFR; PDGFR 740Y-P
M.F/FormulaC141H222N43O39PS3
M.W/Mr.3270.72
SequenceOne Letter Code: RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS
Three Letter Code: Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{PO2-Tyr}-Met-Asp-Met-Ser
Biological ActivityCell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
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